Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Calcif Tissue Int. 2018 May;102(5):522-532. doi: 10.1007/s00223-017-0370-4. Epub 2017 Dec 4.
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells. Furthermore, we summarize the current knowledge about neutralizing antibodies to the antiresorptive protein osteoprotegerin, which have been described in patients with Coeliac Disease, Rheumatoid Arthritis, and Spondyloarthritis.
许多自身免疫性疾病都与骨骼代谢紊乱有关。由此导致的局部或全身性骨质流失，可通过引起局部骨畸形或脆性骨折而降低患者的生活质量。越来越多的证据表明，抗体直接影响骨内稳态的关键因子，特别是破骨细胞。临床和临床前研究深入了解了与类风湿关节炎（类风湿因子、抗瓜氨酸化蛋白抗体和抗氨甲酰化蛋白抗体）相关的自身抗体的功能，以及它们与骨细胞的炎症无关的相互作用。此外，我们总结了目前关于抗吸收蛋白骨保护素的中和抗体的知识，这些抗体已在乳糜泻、类风湿关节炎和脊柱关节炎患者中被描述。
