Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Adv Exp Med Biol. 2017;1041:33-53. doi: 10.1007/978-3-319-69194-7_4.
Hematopoietic stem cells (HSCs) posses the ability to maintain the blood system of an organism from birth to adulthood. The behavior of HSCs is modulated by its microenvironment. During development, HSCs acquire the instructions to self-renew and differentiate into all blood cell fates by passing through several developmental microenvironments. In this chapter, we discuss the signals and cell types that inform HSC decisions throughout ontogeny with a focus on HSC specification, mobilization, migration, and engraftment.
造血干细胞（HSCs）具有从出生到成年维持生物体血液系统的能力。HSCs 的行为受其微环境调节。在发育过程中，HSCs 通过经历几个发育微环境获得自我更新和分化为所有血细胞命运的指令。在本章中，我们讨论了在整个个体发生过程中告知 HSC 决策的信号和细胞类型，重点讨论了 HSC 的特化、动员、迁移和植入。
