Affiliated Hospital of Guangdong Medical University and Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University, Zhanjiang, Guangdong, China.
South China University of Technology, School of Medicine, Guangzhou, Guangdong, China.
Adv Exp Med Biol. 2023;1442:137-157. doi: 10.1007/978-981-99-7471-9_9.
Hematopoiesis is a complex process that tightly regulates the generation, proliferation, differentiation, and maintenance of hematopoietic cells. Disruptions in hematopoiesis can lead to various diseases affecting both hematopoietic and non-hematopoietic systems, such as leukemia, anemia, thrombocytopenia, rheumatoid arthritis, and chronic granuloma. The zebrafish serves as a powerful vertebrate model for studying hematopoiesis, offering valuable insights into both hematopoietic regulation and hematopoietic diseases. In this chapter, we present a comprehensive overview of zebrafish hematopoiesis, highlighting its distinctive characteristics in hematopoietic processes. We discuss the ontogeny and modulation of both primitive and definitive hematopoiesis, as well as the microenvironment that supports hematopoietic stem/progenitor cells. Additionally, we explore the utility of zebrafish as a disease model and its potential in drug discovery, which not only advances our understanding of the regulatory mechanisms underlying hematopoiesis but also facilitates the exploration of novel therapeutic strategies for hematopoietic diseases.
造血是一个复杂的过程，它严格调控着造血细胞的生成、增殖、分化和维持。造血功能的紊乱可导致各种疾病，影响造血和非造血系统，如白血病、贫血、血小板减少症、类风湿关节炎和慢性肉芽肿。斑马鱼是研究造血的强大脊椎动物模型，为造血调控和造血疾病提供了有价值的见解。在本章中，我们全面概述了斑马鱼的造血，强调了其在造血过程中的独特特征。我们讨论了原始和确定性造血的个体发生和调节，以及支持造血干细胞/祖细胞的微环境。此外，我们还探讨了斑马鱼作为疾病模型的用途及其在药物发现中的潜力，这不仅增进了我们对造血调控机制的理解，还有助于探索造血疾病的新型治疗策略。
