Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute , G.B. Marg, Bhavnagar 364 002, Gujarat, India.
J Org Chem. 2017 Dec 15;82(24):13632-13642. doi: 10.1021/acs.joc.7b02211. Epub 2017 Dec 5.
We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions.
我们报道了一种新颖且高效的方法，使用催化量的 I 和 TBHP 作为绿色氧化剂，通过苄位碳的 C-H 键断裂，在温和的反应条件下将苄基碳（胺和氰基）氧化成相应的苯甲酰胺。根据文献调查，这是首例在无金属条件下一锅法实现苄基胺的氧化酰胺化和苄基氰化物的脱氰反应的报道。
Zotero 插件