Wijarnpreecha Karn, Panjawatanan Panadeekarn, Thongprayoon Charat, Jaruvongvanich Veeravich, Ungprasert Patompong
Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA.
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Saudi J Gastroenterol. 2017 Nov-Dec;23(6):311-317. doi: 10.4103/sjg.SJG_161_17.
BACKGROUND/AIM: The relationship between gastroesophageal reflux disease (GERD) and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in recent epidemiologic studies although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of NAFLD among patients with GERD.
Comprehensive literature review was conducted using MEDLINE and EMBASE database from inception through November 2016, to identify studies that compared the risk of NAFLD among patients with GERD versus those without GERD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.
Eight studies (four cross-sectional studies and four case-control studies) with 31,322 participants met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD among patients with GERD was significantly higher than those without GERD with the pooled odds ratio of 2.07 (95% confidence interval, 1.54-2.79). The statistical heterogeneity was high with an I2 of 87%.
A significantly increased risk of NAFLD among patients with GERD was observed in this meta-analysis.
背景/目的：尽管近期流行病学研究结果并不一致，但已证实胃食管反流病（GERD）与非酒精性脂肪性肝病（NAFLD）之间存在关联。本荟萃分析旨在汇总所有可用数据，并评估GERD患者患NAFLD的风险。
使用MEDLINE和EMBASE数据库，对从数据库建立至2016年11月期间的文献进行全面回顾，以确定比较GERD患者与非GERD患者患NAFLD风险的研究。提取每项研究的效应估计值，并采用DerSimonian和Laird的随机效应、通用逆方差法进行合并。
八项研究（四项横断面研究和四项病例对照研究）共31322名参与者符合纳入标准，被纳入荟萃分析。GERD患者患NAFLD的风险显著高于非GERD患者，合并比值比为2.07（95%置信区间为1.54 - 2.79）。统计异质性较高，I²为87%。
本荟萃分析观察到GERD患者患NAFLD的风险显著增加。
