非酒精性脂肪性肝病与心房颤动之间的关联：一项荟萃分析。
The association between non-alcoholic fatty liver disease and atrial fibrillation: A meta-analysis.
作者信息
Wijarnpreecha Karn, Boonpheng Boonphiphop, Thongprayoon Charat, Jaruvongvanich Veeravich, Ungprasert Patompong
机构信息
Department of Internal Medicine, Bassett Medical Center, One Atwell Road, Cooperstown 13326, NY, USA.
Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
出版信息
Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):525-532. doi: 10.1016/j.clinre.2017.08.001. Epub 2017 Aug 31.
BACKGROUND/OBJECTIVES: The association between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) has been suggested by recent epidemiological studies although the results were inconsistent. This meta-analysis was conducted to summarize all available data.
METHODS
A comprehensive literature review was conducted using MEDLINE and EMBASE database through May 2017 to identify all studies that reported the risk of AF among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
RESULTS
Of 1009 studies, 5 studies (two cross-sectional studies and three cohort studies) with 238,129 participants met the eligibility criteria and were included in the meta-analysis. The risk of AF in patients with NAFLD was significantly higher than subjects without NAFLD with the pooled risks ratio of 2.06 (95% confidence interval, 1.10-3.85). The statistical heterogeneity was high with an I of 78%, which was the major limitation of this meta-analysis.
CONCLUSIONS
A significantly increased risk of AF among patients with NAFLD was demonstrated in this study.
背景/目的：近期流行病学研究提示非酒精性脂肪性肝病（NAFLD）与心房颤动（AF）之间存在关联，尽管结果并不一致。本荟萃分析旨在总结所有可用数据。
方法
通过检索MEDLINE和EMBASE数据库，对截至2017年5月的文献进行全面回顾，以确定所有报告NAFLD患者与非NAFLD患者发生AF风险的研究。提取每项研究的效应估计值，并使用DerSimonian和Laird的随机效应、通用逆方差方法进行合并。
结果
在1009项研究中，5项研究（2项横断面研究和3项队列研究，共238,129名参与者）符合纳入标准并被纳入荟萃分析。NAFLD患者发生AF的风险显著高于非NAFLD患者，合并风险比为2.06（95%置信区间，1.10 - 3.85）。统计异质性较高，I²为78%，这是本荟萃分析的主要局限性。
结论
本研究表明NAFLD患者发生AF的风险显著增加。
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