Luvira Vor, Pugkhem Ake, Bhudhisawasdi Vajarabhongsa, Uttaravichien Thong-Ueb, Sripanuskul Anan, Pongskul Jongruk, Pairojkul Chawalit
From the Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Exp Clin Transplant. 2019 Oct;17(5):688-691. doi: 10.6002/ect.2017.0121. Epub 2017 Dec 5.
Intraductal papillary neoplasm of the bile duct is now considered to be a specific type of bile duct tumor. The progenitor cells of intraductal papillary neoplasms of the bile duct are located in the peribiliary gland, which are distributed along the intrahepatic bile duct, extrahepatic bile duct, and gallbladder; therefore, these neoplasms could arise in any area. The mainstay of treatment for patients with intraductal papillary neoplasm of the bile duct is complete surgical resection. Neoplasms involving both lobes of the liver can only be treated with liver transplant. There have been 11 reported cases of patients with biliary papillomatosis treated with liver transplant. In all of these cases, involvement was limited to the bile duct. Herein, we present the first case of papillomatosis with extensive involvement in the intrahepatic bile duct, the extrahepatic bile duct, and the gallbladder, which was successfully treated with repeated resection and liver transplant.
胆管内乳头状肿瘤现在被认为是一种特定类型的胆管肿瘤。胆管内乳头状肿瘤的祖细胞位于沿肝内胆管、肝外胆管和胆囊分布的胆管周围腺体中；因此，这些肿瘤可发生于任何区域。胆管内乳头状肿瘤患者的主要治疗方法是完整的手术切除。累及肝脏两叶的肿瘤只能通过肝移植治疗。已有11例胆管乳头状瘤病患者接受肝移植治疗的报道。在所有这些病例中，受累仅限于胆管。在此，我们报告首例广泛累及肝内胆管、肝外胆管和胆囊的乳头状瘤病，经反复切除和肝移植成功治疗。
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