Ponce J, Garrigues V, Sala T, Pertejo V, Berenguer J
Gastroenterology Unit, Hospital La Fe, Valencia, Spain.
Dig Dis Sci. 1989 Mar;34(3):367-71. doi: 10.1007/BF01536257.
We studied the motility of the sphincter of Oddi in 12 patients with suspected sphincter of Oddi dysfunction, in four patients with cystic dilatation of the bile ducts (two Caroli's cases and two fusiform choledochal cyst cases), and in 33 patients with retained common duct stones. In these last 33 patients, the motor activity of the sphincter of Oddi was similar to that recorded in nine control subjects without pancreatic or biliary diseases. In the suspected Oddi dysfunction cases, both the basal sphincteric pressure and the frequency of the phasic contractions were significantly elevated (P less than 0.001). Patients with biliary cystic dilatation showed an increased basal pressure, but the frequency of the contractions was elevated in only those with choledochal cysts and the amplitude in only one of the two patients with Caroli's disease. Motor disorders of the sphincter of Oddi provide a basis for an alternative etiopathogenesis of cystic disease of the biliary system and a possible explanation for pain and dilatation of the bile duct in patients with suspected sphincter of Oddi dysfunction.
我们研究了12例疑似Oddi括约肌功能障碍患者、4例胆管囊性扩张患者（2例卡罗利病和2例梭形胆总管囊肿）以及33例胆总管结石残留患者的Oddi括约肌运动功能。在这33例胆总管结石残留患者中，Oddi括约肌的运动活性与9例无胰腺或胆道疾病的对照受试者所记录的相似。在疑似Oddi功能障碍的病例中，基础括约肌压力和相性收缩频率均显著升高（P<0.001）。胆管囊性扩张患者基础压力升高，但仅胆总管囊肿患者的收缩频率升高，而卡罗利病的2例患者中只有1例的收缩幅度升高。Oddi括约肌运动障碍为胆道系统囊性疾病的另一种病因发病机制提供了依据，并可能解释疑似Oddi括约肌功能障碍患者的疼痛和胆管扩张。
