Toouli J, Roberts-Thomson I C, Dent J, Lee J
Gastroenterology. 1985 May;88(5 Pt 1):1243-50. doi: 10.1016/s0016-5085(85)80086-x.
Sphincter of Oddi (SO) manometry was conducted in 48 subjects who had previously undergone cholecystectomy. Ten of these subjects had no detectable biliary or pancreatic disease and served as controls. The other 38 patients were presumed to have SO dysfunction and had presented with episodes of severe biliary-type pain with either dilatation of the bile duct on a retrograde cholangiogram, transient changes in liver function tests, or both of these abnormalities. A triple-lumen low-compliance manometric system was used to record the SO basal pressure, SO phasic contraction amplitude, SO wave frequency, direction of wave propagation, and SO response to intravenously administered cholecystokinin-octapeptide 20 ng/kg. Satisfactory manometric recordings were obtained from 32 of 38 patients and of these, 25 patients showed one or more abnormalities when compared with data from the 10 controls. The abnormalities included excess of retrograde contractions (12), high frequency of SO phasic contractions (11), elevation of the SO basal pressure (8), and paradoxical cholecystokinin-octapeptide response (10). The study has demonstrated a spectrum of manometric abnormalities in the SO of patients with suspected SO dysfunction.
对48例曾接受胆囊切除术的受试者进行了Oddi括约肌（SO）测压。其中10名受试者未检测到胆道或胰腺疾病，作为对照。其他38例患者被推测存在SO功能障碍，表现为严重胆绞痛发作，伴有逆行胆管造影显示胆管扩张、肝功能检查的短暂变化或这两种异常情况。使用三腔低顺应性测压系统记录SO基础压力、SO相性收缩幅度、SO波频率、波传播方向以及SO对静脉注射20 ng/kg胆囊收缩素八肽的反应。38例患者中有32例获得了满意的测压记录，与10名对照者的数据相比，其中25例患者表现出一种或多种异常。异常包括逆行收缩过多（12例）、SO相性收缩频率高（11例）、SO基础压力升高（8例）以及胆囊收缩素八肽反应异常（10例）。该研究证明了疑似SO功能障碍患者的SO存在一系列测压异常。
