Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University , Changchun 130024, China.
State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116024, China.
Org Lett. 2017 Dec 15;19(24):6542-6545. doi: 10.1021/acs.orglett.7b03254. Epub 2017 Dec 5.
A silver-catalyzed, defluorination ring-opening diarylation of siloxy 2,2-difluorocyclopropanes, with two arenes, to directly prepare polysubstituted 2-fluoroallylic compounds, is described. This multicomponent reaction proceeds smoothly in good stereoselectivity, which is due to a chelation-controlled addition of arenes to α-fluorinated ketone intermediate.
本文描述了一种银催化的、脱氟开环二芳基化反应，用于硅氧基 2,2-二氟环丙烷，与两个芳基反应，直接制备多取代的 2-氟烯丙基化合物。该多组分反应以良好的立体选择性顺利进行，这归因于芳基与α-氟化酮中间体的螯合控制加成。
