Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Dev Cell. 2017 Dec 4;43(5):543-544. doi: 10.1016/j.devcel.2017.11.012.
Within tumors, macrophage infiltration can promote cancer cell invasiveness and, consequently, metastatic dissemination. In this issue of Developmental Cell, Roh-Johnson et al. (2017) reveal that cytoplasmic transfer from macrophages to melanoma cells correlates with melanoma invasion and arises as a result of intimate cell-cell contact.
在肿瘤中，巨噬细胞浸润可以促进癌细胞的侵袭性，进而促进转移性扩散。在本期《发育细胞》中，Roh-Johnson 等人（2017）揭示了巨噬细胞向黑色素瘤细胞的细胞质转移与黑色素瘤的侵袭相关，并且这种转移是由于细胞间的紧密接触而产生的。
