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血必净注射液中羟基红花黄色素 A 的稳定性及其机制。

Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism.

机构信息

Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

出版信息

Molecules. 2017 Dec 2;22(12):2129. doi: 10.3390/molecules22122129.

DOI:10.3390/molecules22122129
PMID:29207486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149961/
Abstract

Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of XBJ injection. At first, the stability of HSYA in solution and in a Xuebijing injection was investigated, then the mechanisms of the increased stability of HSYA in the XBJ injection were investigated to provide useful information on clinical safety. HSYA stability was investigated as a function of pH and temperature in aqueous solution and an XBJ injection, following the guidelines from the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Products were identified by UPLC-MS/MS. HSYA reaction followed first-order kinetics under all conditions. The half-life of HSYA in XBJ was almost 40 times longer than in aqueous solution. The activation energies of HSYA reaction in aqueous solution and XBJ were calculated to be 78.53 and 92.90 kJ∙mol by using Arrhenius equation. The results indicated that HSYA was more stable in XBJ than in aqueous solution. Two products were identified and the mechanism was intra-molecular nucleophilic substitution. The excellent stability of HSYA in XBJ injection partly due to the micelles formed in the injection. The study may provide clues for compatibility in TCM prescription and also provide useful information for further preparation technology research of HSYA and assessment of clinical safety of XBJ.

摘要

羟基红花黄色素 A（HSYA）是血必净注射液的主要生物活性成分。首先，考察了 HSYA 在溶液中和血必净注射液中的稳定性，然后研究了 HSYA 在血必净注射液中稳定性增加的机制，为临床安全性提供了有用的信息。根据人用药品注册技术要求国际协调会的指导原则，考察了 HSYA 在水溶液和血必净注射液中的 pH 和温度对其稳定性的影响。采用 UPLC-MS/MS 对产物进行了鉴定。在所有条件下，HSYA 的反应均遵循一级动力学。HSYA 在血必净中的半衰期几乎是在水溶液中的 40 倍。通过阿仑尼乌斯方程计算，HSYA 在水溶液和血必净中的反应活化能分别为 78.53 和 92.90 kJ·mol。结果表明，HSYA 在血必净中的稳定性优于在水溶液中。鉴定出两种产物，其机制为分子内亲核取代。HSYA 在血必净注射液中具有良好的稳定性，部分原因是注射液中形成了胶束。该研究可能为中药方剂的相容性提供线索，也为进一步研究 HSYA 的制备技术和评估血必净的临床安全性提供有用信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/b31162b10a76/molecules-22-02129-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/54a5ad6ed2fb/molecules-22-02129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/35b6a704b791/molecules-22-02129-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/9d3b8211d941/molecules-22-02129-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/7626e575d5fc/molecules-22-02129-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/9fef52c30d34/molecules-22-02129-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/6a261af06099/molecules-22-02129-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/de3fcc3139ab/molecules-22-02129-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/732e16139717/molecules-22-02129-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/b31162b10a76/molecules-22-02129-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/54a5ad6ed2fb/molecules-22-02129-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/35b6a704b791/molecules-22-02129-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/9d3b8211d941/molecules-22-02129-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/7626e575d5fc/molecules-22-02129-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/9fef52c30d34/molecules-22-02129-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/6a261af06099/molecules-22-02129-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/de3fcc3139ab/molecules-22-02129-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/732e16139717/molecules-22-02129-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d49e/6149961/b31162b10a76/molecules-22-02129-g008.jpg

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本文引用的文献

1
Study of relative response factors and mass balance in forced degradation studies with liquid chromatography/photo-diode array detector/evaporative light scattering detector/mass spectrometry system.
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2
Stability Testing of Herbal Drugs: Challenges, Regulatory Compliance and Perspectives.草药稳定性测试：挑战、法规遵从性与展望
Phytother Res. 2016 Jul;30(7):1046-58. doi: 10.1002/ptr.5618. Epub 2016 Apr 13.
3
Aqueous solubility and degradation kinetics of the phytochemical anticancer thymoquinone; probing the effects of solvents, pH and light.植物化学抗癌成分百里醌的水溶性及降解动力学；探究溶剂、pH值和光照的影响
血必净注射液维持GRP78表达以预防顺铂诱导的肾上皮细胞死亡。
Front Pharmacol. 2020 Jan 6;10:1416. doi: 10.3389/fphar.2019.01416. eCollection 2019.
Molecules. 2014 May 8;19(5):5925-39. doi: 10.3390/molecules19055925.
4
Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF.基于生物活性整合 UPLC-Q/TOF 的血必净注射液治疗脓毒症的 NF-κB 抑制剂的鉴定。
J Ethnopharmacol. 2013 May 20;147(2):426-33. doi: 10.1016/j.jep.2013.03.032. Epub 2013 Mar 22.
5
Multiscale study on the interaction mechanism between ginsenoside biosurfactant and saikosaponin a.人参皂苷生物表面活性剂与柴胡皂苷 a 相互作用机制的多尺度研究。
J Colloid Interface Sci. 2013 Apr 15;396:165-72. doi: 10.1016/j.jcis.2013.01.017. Epub 2013 Jan 25.
6
Degradation kinetics of atorvastatin under stress conditions and chemical analysis by HPLC.阿托伐他汀在应激条件下的降解动力学及 HPLC 化学分析。
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7
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8
Degradation kinetics of anthocyanins from European cranberrybush (Viburnum opulus L.) fruit extracts. Effects of temperature, pH and storage solvent.欧洲越橘果实提取物中花色苷的降解动力学。温度、pH 值和储存溶剂的影响。
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9
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J Ethnopharmacol. 2012 Feb 15;139(3):746-50. doi: 10.1016/j.jep.2011.11.054. Epub 2011 Dec 17.