羟基红花黄色素 A 对裸鼠人胃癌 BGC-823 移植瘤肿瘤血管生成的影响。
Effects of hydroxy safflower yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.
机构信息
Department of Traditional Chinese Medicine of Medical College of Xiamen University, Xiamen, Fujian 361005, China.
出版信息
J Tradit Chin Med. 2012 Jun;32(2):243-8. doi: 10.1016/s0254-6272(13)60019-9.
OBJECTIVE
To study the effects of hydroxy safflower yellow A (HSYA) on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.
METHODS
BGC-823 cells were injected subcutaneously into the right anterior armpit of nude mice to establish an animal model of transplanted tumors. After 24 h, 18 nude mice injected with tumor cells were randomized into model, control, and HSYA 0.028 g/L groups, with six mice in each group. Transplanted tumors were excised on day 20. Tumor inhibition ratios were calculated for the transplanted tumors. Pathological changes and capillary angiogenesis in the tumors were observed by light microscopy.
RESULTS
Tumors in the model group grew more quickly than those in the control and HSYA groups, with inhibition ratios of 48% and 30%, respectively. The microvessel count in the HSYA group was lower than in the model group (P < 0.01), and microvessel density was also lower in the HSYA group (P < 0.05). Pathological changes were more obvious in tumors in the model group compared to the HSYA group.
CONCLUSION
HSYA inhibits the growth of transplanted BGC-823 tumors, and its effects on tumor capillary angiogenesis may represent one of the mechanisms responsible for this antineoplastic effect.
目的
研究羟基红花黄色素 A（HSYA）对裸鼠人胃癌 BGC-823 移植瘤肿瘤血管生成的影响。
方法
将 BGC-823 细胞皮下注射于裸鼠右前腋窝，建立裸鼠移植瘤动物模型。接种 24 h 后，将 18 只荷瘤裸鼠随机分为模型组、对照组和 HSYA 0.028 g/L 组，每组 6 只。于第 20 天切除移植瘤，计算移植瘤抑制率。光镜下观察肿瘤的病理变化和血管生成情况。
结果
模型组肿瘤生长速度快于对照组和 HSYA 组，抑制率分别为 48%和 30%。HSYA 组微血管计数低于模型组（P<0.01），微血管密度也低于模型组（P<0.05）。与 HSYA 组相比，模型组肿瘤的病理变化更为明显。
结论
HSYA 抑制 BGC-823 移植瘤的生长，其对肿瘤血管生成的抑制作用可能是其抗肿瘤作用的机制之一。
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