Broussolle E, Darriet D, Debilly G, Pujol J F, Bobillier P
Groupe de Neurochimie Fonctionnelle, INSERM U 171-CNRS UA 1195, Centre Hospitalier Lyon-Sud, Pierre, Benite, France.
Eur J Pharmacol. 1989 Jan 17;159(3):225-31. doi: 10.1016/0014-2999(89)90152-0.
The effect of a new eburnamine derivative, RU 24722, a putative phasic activator of catecholaminergic systems on local cerebral glucose utilization was studied in freely moving rats 15 min, 90 min and 6 h after the intraperitoneal administration of the drug (25 mg/kg). Of the 53 brain regions examined, 9 exhibited significant time-dependent increases of glucose utilization (up to 45-55%). Some changes were early and transient, as in the substantia nigra reticulata and the paraventricular nuclei. Other areas showed sustained (median septal nucleus) or delayed increases of glucose utilization (lateral septum, dorsal subiculum, hippocampal fimbria, fronto-parietal motor cortex and ventral cochlear nucleus). No significant alterations of glucose utilization could be elicited in the locus coeruleus and raphe nuclei, and none of the brain regions showed a decrease in glucose consumption. Our findings suggest that RU 24722 preferentially stimulates the activity in some brain areas involved in cognitive, vegetative and locomotor functions.
在自由活动的大鼠腹腔注射药物（25mg/kg）后15分钟、90分钟和6小时，研究了一种新的刺桐胺衍生物RU 24722（一种假定的儿茶酚胺能系统的阶段性激活剂）对局部脑葡萄糖利用的影响。在所检查的53个脑区中，9个脑区的葡萄糖利用呈现出显著的时间依赖性增加（高达45%-55%）。一些变化是早期和短暂的，如黑质网状部和室旁核。其他区域则表现出葡萄糖利用的持续增加（内侧隔核）或延迟增加（外侧隔核、背侧海马下托、海马伞、额顶运动皮层和腹侧耳蜗核）。在蓝斑和中缝核中未引起葡萄糖利用的显著改变，且没有一个脑区的葡萄糖消耗减少。我们的研究结果表明，RU 24722优先刺激一些参与认知、自主和运动功能的脑区的活动。
