Borzeix M G, Cahn J
Int J Clin Pharmacol Res. 1984;4(4):259-61.
Alkyltin compounds are known to produce in the rat a selective oedema of the CNS, especially of the white matter. Vincamine and vincamine derivatives, among which Teproside is the most potent, are able to prevent the occurrence of such an oedematous reaction whereas xanthine derivatives and papaverine fail to prevent this oedema. It is suggested that there may be a potentiation of the effect of vincamine by the xanthine part of the Teproside chemical structure.
已知烷基锡化合物可在大鼠中引起中枢神经系统的选择性水肿，尤其是白质水肿。长春胺及其衍生物（其中泰普罗甙最为有效）能够预防这种水肿反应的发生，而黄嘌呤衍生物和罂粟碱则无法预防这种水肿。有人认为，泰普罗甙化学结构中的黄嘌呤部分可能会增强长春胺的作用效果。
