Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, United States.
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, United States; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, 4710-057, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugal.
Semin Cell Dev Biol. 2018 Oct;82:57-66. doi: 10.1016/j.semcdb.2017.11.033. Epub 2017 Dec 6.
During development of the mammalian brain, neural stem cells divide and give rise to adult stem cells, glia and neurons, which migrate to their final locations. Nuclear migration is an important feature of neural stem cell (radial glia progenitor) proliferation and subsequent postmitotic neuronal migration. Defects in nuclear migration contribute to severe neurodevelopmental disorders such as microcephaly and lissencephaly. In this review, we address the cellular and molecular mechanisms responsible for nuclear migration during the radial glia cell cycle and postmitotic neuronal migration, with a particular focus on the role of molecular motors and cytoskeleton dynamics in regulating nuclear behavior.
在哺乳动物大脑的发育过程中，神经干细胞分裂并产生成体干细胞、神经胶质细胞和神经元，这些细胞迁移到它们的最终位置。核迁移是神经干细胞（放射状胶质祖细胞）增殖和随后的有丝后神经元迁移的重要特征。核迁移缺陷导致严重的神经发育障碍，如小头畸形和无脑回畸形。在这篇综述中，我们讨论了在放射状胶质细胞周期和有丝后神经元迁移过程中负责核迁移的细胞和分子机制，特别关注分子马达和细胞骨架动力学在调节核行为中的作用。
