Department of Psychology, Seton Hall University, South Orange, NJ, USA.
Stroke Rehabilitation Research, Kessler Foundation, West Orange, NJ, USA.
Neuropsychol Rehabil. 2020 Jan;30(1):32-53. doi: 10.1080/09602011.2018.1448287. Epub 2018 Mar 20.
Spatial neglect commonly follows right hemisphere stroke. It is defined as impaired contralesional stimulus detection, response, or action, causing functional disability. While prism adaptation treatment is highly promising to promote functional recovery of spatial neglect, not all individuals respond. Consistent with a primary effect of prism adaptation on spatial movements, we previously demonstrated that functional improvement after prism adaptation treatment is linked to frontal lobe lesions. However, that study was a treatment-only study with no randomised control group. The current study randomised individuals with spatial neglect to receive 10 days of prism adaptation treatment or to receive only standard care (control group). Replicating our earlier results, we found that the presence of frontal lesions moderated response to prism adaptation treatment: among prism-treated patients, only those with frontal lesions demonstrated functional improvements in their neglect symptoms. Conversely, among individuals in the standard care control group, the presence of frontal lesions did not modify recovery. These results suggest that further research is needed on how frontal lesions may predict response to prism adaptation treatment. Additionally, the results help elucidate the neural network involved in spatial movement and could be used to aid decisions about treatment.
空间忽略通常发生在右脑中风后。它被定义为对侧刺激检测、反应或动作受损，导致功能障碍。虽然棱镜适应治疗对促进空间忽略的功能恢复有很高的前景，但并非所有人都有反应。与棱镜适应对空间运动的主要影响一致，我们之前的研究表明，棱镜适应治疗后的功能改善与额叶损伤有关。然而，该研究只是一项治疗研究，没有随机对照组。本研究将空间忽略的个体随机分为接受 10 天棱镜适应治疗或仅接受标准护理（对照组）。我们复制了之前的结果，发现额叶损伤会影响对棱镜适应治疗的反应：在接受棱镜治疗的患者中，只有额叶损伤的患者的忽略症状有功能改善。相反，在标准护理对照组中，额叶损伤的存在并不能改变恢复情况。这些结果表明，需要进一步研究额叶损伤如何预测对棱镜适应治疗的反应。此外，这些结果有助于阐明涉及空间运动的神经网络，并可用于辅助治疗决策。
