内质网伴侣蛋白在肿瘤发生过程中调节化生的新作用。
New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.
作者信息
Shen Jieli, Rangel Daisy F, Ha Dat, Lee Amy S
机构信息
Department of Biochemistry and Molecular Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Mol Cell Oncol. 2017 Jun 30;4(6):e1345350. doi: 10.1080/23723556.2017.1345350. eCollection 2017.
Abstract
Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.
摘要
化生正逐渐成为肿瘤发生过程中的一个关键环节。我们发现，两种内质网（ER）分子伴侣，即78千道尔顿葡萄糖调节蛋白（GRP78）和94千道尔顿葡萄糖调节蛋白（GRP94）在化生过程中发挥作用。小鼠胰腺中Grp78单倍体不足会损害腺泡-导管化生，而在子宫中，Grp94缺失会诱导鳞状细胞化生；两者均导致肿瘤抑制。
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