Stjepanovic Goran, Baskaran Sulochanadevi, Lin Mary G, Hurley James H
Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Mol Cell Oncol. 2017 Sep 18;4(6):e1367873. doi: 10.1080/23723556.2017.1367873. eCollection 2017.
The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex and mechanisms that regulate VPS34 activity at the membrane.
III类磷脂酰肌醇3激酶VPS34形成不同的复合物，这些复合物对于内吞作用中的货物分选和膜运输以及自噬体的成核和成熟至关重要。我们使用综合结构生物学方法来深入了解该复合物的构象动力学以及在膜上调节VPS34活性的机制。
