Weichert W, Ihrler S, Boxberg M, Agaimy A, Mollenhauer M, Hartmann A
Institut für Pathologie, Technische Universität München (TUM), Trogerstr. 18, 81675, München, Deutschland.
Labor für Dermatohistologie und Oralpathologie, München, Deutschland.
Pathologe. 2018 Feb;39(1):3-10. doi: 10.1007/s00292-017-0395-5.
Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. The morphology of HNSCC comprises a spectrum of growth patterns. In addition, special types of HNSCC must be delineated. Recently, for virus-associated HNSCC, some important clinicopathological specifics have become relevant including a separate staging system for these neoplasms. For non-virus associated HNSCC, new grading procedures have been proposed, which significantly impact on prognosis. These issues will be discussed in this review.
头颈部鳞状细胞癌（HNSCC）是目前该解剖区域最常见的恶性肿瘤。如今，HNSCC被分为两种在形态学、分子学和临床方面存在根本差异的实体：传统型和病毒相关型（HPV/EBV）肿瘤。非病毒相关型HNSCC的癌前病变包括传统型白斑、发育异常和增殖性疣状增生，其恶变风险不断增加。HNSCC的形态学包括一系列生长模式。此外，必须明确HNSCC的特殊类型。最近，对于病毒相关型HNSCC，一些重要的临床病理特征变得至关重要，包括针对这些肿瘤的单独分期系统。对于非病毒相关型HNSCC，已经提出了新的分级程序，这对预后有重大影响。这些问题将在本综述中进行讨论。
