University of California, San Francisco, Trinity College Dublin, Dublin, Ireland, Monash University School of Public Health and Preventive Medicine, Melbourne, Victoria, Australia, University of Queensland School of Public Health, Brisbane, Queensland, Australia, and Arthritis Research UK Centre for Sport Exercise and Osteoarthritis, Nottingham, UK.
Arthritis Research UK Centre for Sport Exercise and Osteoarthritis and the University of Nottingham School of Medicine, Nottingham, UK.
Arthritis Care Res (Hoboken). 2018 Jul;70(7):1012-1021. doi: 10.1002/acr.23430. Epub 2018 May 18.
To examine whether body mass index (BMI), menopausal status, and hormone therapy (HT) use modify the association between physical activity (PA) patterns throughout middle age and the incidence and prevalence of joint symptoms in women in later middle age.
Data were from 6,661 participants (born 1946-1951) in the Australian Longitudinal Study on Women's Health. Surveys, with questions on joint pain and stiffness, PA, height and weight, menopausal symptoms, and HT use, were completed every 3 years from 1998 to 2010. PA patterns were defined as none or low, low or meeting guidelines, fluctuating, or meeting guidelines at all times (reference pattern). Logistic regression was used to examine the association between PA patterns and prevalent (in 2010) and cumulative incident (1998-2010) joint symptoms and effect modification by patterns in BMI, menopausal status, and HT.
The groups representing fluctuating PA (odds ratio [OR] 1.34 [99% confidence interval (99% CI) 1.04-1.72]) and no or low PA (OR 1.60 [99% CI 1.08-2.35]) had higher odds of incident joint symptoms than those described as meeting guidelines at all times. Stratification by BMI showed that this association was statistically significant in the obese group only. No evidence for effect modification by menopausal status or HT use was found. The findings were similar for prevalent joint symptoms.
Maintaining at least low levels of PA throughout middle age was associated with a lower prevalence and incidence of joint symptoms later in life. This apparent protective effect of PA on joint symptoms was stronger in obese women than in under- or normal-weight women, and not related to menopause or HT status.
研究身体质量指数（BMI）、绝经状态和激素疗法（HT）的使用是否会改变中年时期的体力活动（PA）模式与中老年女性关节症状的发生和流行之间的关联。
数据来自澳大利亚女性健康纵向研究的 6661 名参与者（出生于 1946-1951 年）。1998 年至 2010 年期间，每隔 3 年进行一次调查，内容包括关节疼痛和僵硬、PA、身高和体重、绝经症状和 HT 使用情况。PA 模式定义为无或低、低或符合指南、波动或始终符合指南（参考模式）。使用逻辑回归检验 PA 模式与流行（2010 年）和累积性（1998-2010 年）关节症状之间的关联，并检验 BMI、绝经状态和 HT 模式的变化对这种关联的影响。
波动 PA 组（比值比 [OR] 1.34 [99%置信区间 99%CI 1.04-1.72]）和无或低 PA 组（OR 1.60 [99%CI 1.08-2.35]）发生关节症状的可能性高于始终符合指南的组。按 BMI 分层后，仅肥胖组的这种关联具有统计学意义。未发现绝经状态或 HT 使用对这种关联有影响。流行关节症状的结果类似。
在中年时期保持至少低水平的 PA 与晚年较低的关节症状发生率和流行率相关。PA 对关节症状的这种明显保护作用在肥胖女性中比在低体重或正常体重女性中更强，与绝经或 HT 状态无关。
