早发性与晚发性阿尔茨海默病的神经精神特征。
Neuropsychiatric Profile in Early Versus Late Onset Alzheimer's Disease.
机构信息
1 Psychiatry Service, Hospital de Braga, Braga, Portugal.
2 Unidade de Saúde Familiar Duovida, Guimarães, Portugal.
出版信息
Am J Alzheimers Dis Other Demen. 2018 Mar;33(2):93-99. doi: 10.1177/1533317517744061. Epub 2017 Dec 6.
BACKGROUND
The aim of this study was to investigate the frequency and severity of neuropsychiatric symptoms (NPS) in patients with early onset Alzheimer's disease (EAOD) and late onset AD (LOAD).
METHODS
Patients were selected from a specialized memory outpatient clinic. The Mini-Mental State Examination, the Neuropsychiatric Inventory (NPI), and the Global Deterioration Scale results were analyzed.
RESULTS
By comparing EOAD (n = 35) and LOAD (n = 35) patients, no significant differences were found in clinical or demographic variables, matched for sex, education, and disease severity. There were no differences between groups in total NPI frequency or severity scores. The most common NPS were irritability, apathy, anxiety, and depression. We found an association of NPI scores with disease severity and duration, which was more specific in patients with LOAD and was also associated with the presence of delusions and hallucinations.
CONCLUSION
Despite subtle differences, NPS is considered important in the assessment of patients with AD, regardless of the age of onset.
背景
本研究旨在探讨早发性阿尔茨海默病（EOAD）和晚发性 AD（LOAD）患者神经精神症状（NPS）的频率和严重程度。
方法
从专门的记忆门诊中选择患者。分析了 Mini-Mental State Examination、Neuropsychiatric Inventory（NPI）和 Global Deterioration Scale 的结果。
结果
通过比较 EOAD（n = 35）和 LOAD（n = 35）患者，在性别、教育程度和疾病严重程度相匹配的情况下，两组在临床或人口统计学变量上无显著差异。两组的 NPI 总频率或严重程度评分无差异。最常见的 NPS 是易怒、冷漠、焦虑和抑郁。我们发现 NPI 评分与疾病严重程度和持续时间相关，在 LOAD 患者中更为具体，并且还与妄想和幻觉的存在相关。
结论
尽管存在细微差异，但 NPS 在 AD 患者的评估中被认为很重要，与发病年龄无关。
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