Ran Xiao-Ku, Win Aung Khin Khin, Bai Jun, Dou Pei-Yuan, Zeng Zheng, Dou De-Qiang
a College of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian 116600 , China.
b College of Pharmacy , Shanxi University of Traditional Chinese Medicine , Taiyuan 030024 , China.
J Asian Nat Prod Res. 2018 Jun;20(6):538-544. doi: 10.1080/10286020.2017.1411346. Epub 2017 Dec 6.
The chemical constituents of 95% EtOH extract of yacon leaves were separated to yield two new sesquiterpene lactones, together with three known compounds. The two new compounds were characterized to be 8β-angeloyloxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (1) and 8β-(3-methylbut-2-enoyl) oxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (2) on the basis of NMR spectra, HR-MS and other spectroscopic methods. The cytotoxicity of compounds 1-5 were evaluated on human hepatoma cell Bel-7402 and all the compounds showed moderate cytotoxicity.
对雪莲果叶95%乙醇提取物的化学成分进行分离，得到两个新的倍半萜内酯以及三个已知化合物。通过核磁共振光谱、高分辨质谱和其他光谱方法鉴定，这两个新化合物分别为8β-当归酰氧基-13-甲氧基-11,13-二氢美兰坡里德-14-酸甲酯（1）和8β-(3-甲基丁-2-烯酰)氧基-13-甲氧基-11,13-二氢美兰坡里德-14-酸甲酯（2）。对化合物1-5在人肝癌细胞Bel-7402上进行细胞毒性评价，所有化合物均表现出中等细胞毒性。
