• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从雪莲果叶中提取的美兰坡利德及其对脂多糖诱导的一氧化氮生成的抑制活性。

Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of lps-induced nitric oxide production.

作者信息

Hong Seong Su, Lee Seon A, Han Xiang Hua, Lee Min Hee, Hwang Ji Sang, Park Jeong Sook, Oh Ki-Wan, Han Kun, Lee Myung Koo, Lee Heesoon, Kim Wook, Lee Dongho, Hwang Bang Yeon

机构信息

College of Pharmacy, Chungbuk National University, Cheongju, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2008 Feb;56(2):199-202. doi: 10.1248/cpb.56.199.

DOI:10.1248/cpb.56.199
PMID:18239309
Abstract

Two new melampolide-type sesquiterpene lactones, 8beta-epoxyangeloyloxy-9alpha-ethoxy-14-oxo-acanthospermolide (1) and 8beta-angeloyloxy-9alpha-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8beta-angeloyloxy-9alpha-acetoxy-14-oxo-acanthospermolide (7), 8beta-angeloyloxy-14-oxo-acanthospermolide (8), 8beta-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8beta-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

摘要

从雪莲果[Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson]的叶子中分离出两种新的倍半萜内酯类化合物，8β-环氧当归酰氧基-9α-乙氧基-14-氧代刺苞菊内酯（1）和8β-当归酰氧基-9α-乙氧基-14-氧代刺苞菊内酯（2），以及十一种已知的倍半萜内酯类化合物，别施库林内酯（3）、恩海德林（4）、多马丁A（5）、弗卢图阿宁（6）、8β-当归酰氧基-9α-乙酰氧基-14-氧代刺苞菊内酯（7）、8β-当归酰氧基-14-氧代刺苞菊内酯（8）、8β-甲基丙烯酰氧基倍半萜内酯-14-甲酸甲酯（9）、乌韦达林（10）、多马丁B（11）、8β-惕各酰氧基倍半萜内酯-14-甲酸甲酯（12）和雪莲果叶苷（13）。它们的结构是根据包括一维和二维核磁共振实验在内的光谱证据确定的。对所有分离物进行了评估，以检测其对小鼠巨噬细胞RAW 264.7细胞中脂多糖诱导的一氧化氮产生的抑制作用。

相似文献

1
Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of lps-induced nitric oxide production.从雪莲果叶中提取的美兰坡利德及其对脂多糖诱导的一氧化氮生成的抑制活性。
Chem Pharm Bull (Tokyo). 2008 Feb;56(2):199-202. doi: 10.1248/cpb.56.199.
2
Purification and identification of antimicrobial sesquiterpene lactones from yacon (Smallanthus sonchifolius) leaves.从雪莲果（菊薯）叶片中纯化和鉴定抗菌倍半萜内酯
Biosci Biotechnol Biochem. 2003 Oct;67(10):2154-9. doi: 10.1271/bbb.67.2154.
3
The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines.来自雪莲果的倍半萜内酯多玛汀B在三种癌细胞系中诱导不同的细胞死亡机制。
Phytochemistry. 2015 Sep;117:332-339. doi: 10.1016/j.phytochem.2015.06.020. Epub 2015 Jun 27.
4
New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines.从 8 个雅笋叶品种（大丽轮枝菌）中提取的新倍半萜内酯二聚体，Uvedafolin：对 HeLa、HL-60 和小鼠 B16-F10 黑色素瘤细胞系的细胞毒性。
J Agric Food Chem. 2015 Dec 23;63(50):10856-61. doi: 10.1021/acs.jafc.5b05229. Epub 2015 Dec 9.
5
Two new sesquiterpene lactones from leaves of yacon, Smallanthus sonchifolius.从雪莲果（Smallanthus sonchifolius）叶片中分离得到的两种新倍半萜内酯。
J Asian Nat Prod Res. 2018 Jun;20(6):538-544. doi: 10.1080/10286020.2017.1411346. Epub 2017 Dec 6.
6
Germacranolide-type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi.来自黄鹌菜的倍半萜内酯类化合物具有抗墨西哥利什曼原虫和克氏锥虫的活性。
Parasit Vectors. 2017 Nov 13;10(1):567. doi: 10.1186/s13071-017-2509-6.
7
Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.从糙叶斑种草中分离得到的两种倍半萜内酯的抗寄生虫活性
J Ethnopharmacol. 2012 May 7;141(1):411-7. doi: 10.1016/j.jep.2012.03.002. Epub 2012 Mar 13.
8
A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging.小白菊内酯在Smallanthus sonchifolius 中的生物合成途径及其在叶片组织中的 MALDI 成像定位。
Chem Commun (Camb). 2013 Nov 4;49(85):9989-91. doi: 10.1039/c3cc46213g.
9
A new sesquiterpene lactone from yacon leaves.从雪莲果叶中分离得到的一种新倍半萜内酯。
Nat Prod Res. 2017 Jan;31(1):43-49. doi: 10.1080/14786419.2016.1212028. Epub 2016 Aug 2.
10
Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata.从齿裂苦荬菜根部分离出两种新型生物活性倍半萜内酯糖苷。
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4562-6. doi: 10.1016/j.bmcl.2015.08.061. Epub 2015 Aug 24.

引用本文的文献

1
Impacts of Yacon Syrup () on Human Health: A Systematic Review of Scientific Evidence from the Last Decade.雪莲果糖浆对人体健康的影响：对过去十年科学证据的系统评价。
Nutrients. 2025 Mar 1;17(5):888. doi: 10.3390/nu17050888.
2
Effects of Flour on Metabolic Parameters: A Systematic Review.面粉对代谢参数的影响：一项系统综述。
Pharmaceuticals (Basel). 2024 May 20;17(5):658. doi: 10.3390/ph17050658.
3
Trypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation.
苦苣菜的杀锥虫活性：通过基于生物测定的分离鉴定活性倍半萜内酯。
Evid Based Complement Alternat Med. 2013;2013:627898. doi: 10.1155/2013/627898. Epub 2013 Jun 6.
4
Yacon (Smallanthus sonchifolius): a functional food.雅甘（小菊苣）：一种功能性食品。
Plant Foods Hum Nutr. 2013 Sep;68(3):222-8. doi: 10.1007/s11130-013-0362-0.
5
Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives.作为潜在抗炎剂的草药的系统评价：最新进展、当前临床状况及未来展望。
Pharmacogn Rev. 2011 Jul;5(10):120-37. doi: 10.4103/0973-7847.91102.
6
Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity.光强条件下雪莲果叶提取物对耐甲氧西林金黄色葡萄球菌的抗菌及协同作用
J Nat Med. 2010 Apr;64(2):212-5. doi: 10.1007/s11418-010-0388-7. Epub 2010 Jan 30.