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巴西南部和东南部地区艾滋病合并结核杆菌感染患者的生存率。

Survival of patients with AIDS and co-infection with the tuberculosis bacillus in the South and Southeast regions of Brazil.

作者信息

Melo Márcio Cristiano de, Donalisio Maria Rita, Cordeiro Ricardo Carlos

机构信息

Departamento de Saúde Coletiva, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. R. Tessália Vieira de Camargo 126, Cidade Universitária. 13083-887 Campinas SP Brasil.

出版信息

Cien Saude Colet. 2017 Nov;22(11):3781-3792. doi: 10.1590/1413-812320172211.26352015.

Abstract

The study investigates the survival of patients with co-infection AIDS-TB through a retrospective study of a cohort of individuals aged 13 or more and the diagnosis of AIDS reported in the years 1998-99 and following 10 years. Of the 2,091 AIDS cases, 517 (24.7%) had positive diagnosis for tuberculosis, and 379 (73.3%) were male. The risk among co-infected patients was 1,65 times the not co-infected. Have been compared the exposed and non-exposed through the Kaplan-Meier and Cox method. The variables associated with longer survival were: female gender (HR = 0.63), educational level ≥ eight years (HR = 0.52), CD4 diagnostic criteria (HR = 0.64); and shorter survival: age ≥ 60 years (HR = 2.33), no use of HAART (HR = 8.62), no investigation to Hepatitis B (HR = 2.44) and opportunistic infections ≥ two (HR = 1.97). The average survival rate, related to TB infection was 69 months for the Southeast region and 73 months for the South. AIDS and tuberculosis require monitoring and treatment adherence and they are markers of the quality of care and survival of patients in Brazil.

摘要

该研究通过对13岁及以上人群的队列进行回顾性研究,并对1998 - 1999年及之后10年报告的艾滋病诊断情况进行调查,以研究艾滋病合并结核病患者的生存率。在2091例艾滋病病例中,517例(24.7%)结核病诊断呈阳性,379例(73.3%)为男性。合并感染患者的风险是未合并感染患者的1.65倍。通过Kaplan - Meier法和Cox法对暴露组和非暴露组进行了比较。与较长生存期相关的变量有:女性性别(风险比=0.63)、教育水平≥8年(风险比=0.52)、CD4诊断标准(风险比=0.64);与较短生存期相关的变量有:年龄≥60岁(风险比=2.33)、未使用高效抗逆转录病毒治疗(风险比=8.62)、未进行乙肝检查(风险比=2.44)以及机会性感染≥2次(风险比=1.97)。与结核病感染相关的平均生存率,东南部地区为69个月,南部地区为73个月。艾滋病和结核病需要监测以及治疗依从性,它们是巴西患者护理质量和生存率的指标。

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