Downarowicz Patrycja, Mikulewicz Marcin
Department of Facial Abnormalities, Wroclaw Medical University, Poland.
Department of Maxillofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Poland.
Adv Clin Exp Med. 2017 Oct;26(7):1155-1162. doi: 10.17219/acem/65726.
An overview of professional literature referring to the release of metal ions from fixed orthodontic appliances and their influence on oral mucosa in conditions of in vivo are presented, along with a detailed analysis of the exposure of the cells of cheek mucosa epithelium to metal ions. Electronic databases (PubMed, Elsevier, Ebsco) were searched with no language restrictions. The relevant orthodontic journals and reference lists were checked for all eligible studies. A total of 38 scientific articles were retrieved in the initial search. However, only 7 articles met the inclusion criteria. Statistically significant differences in the levels of the amount of nickel ions, cobalt ions and chromium ions were observed in cells of cheek mucosa. The most biocompatible material used in the production of fixed orthodontic appliances is titanium, and the least biocompatible material is steel, which releases the largest amount of nickel and chromium. Metal ions are released from fixed orthodontic appliances only in the first phase of treatment. It is recommended to conduct further, long-term research on a larger number of patients to define the influence of using fixed orthodontic appliances and biological effect they might have on tissues.
本文概述了关于固定正畸矫治器释放金属离子及其在体内条件下对口腔黏膜影响的专业文献，并详细分析了颊黏膜上皮细胞暴露于金属离子的情况。检索了电子数据库（PubMed、Elsevier、Ebsco），无语言限制。对所有符合条件的研究，检查了相关正畸期刊和参考文献列表。初步检索共检索到38篇科学文章。然而，只有7篇文章符合纳入标准。在颊黏膜细胞中观察到镍离子、钴离子和铬离子含量水平存在统计学显著差异。固定正畸矫治器生产中使用的生物相容性最佳的材料是钛，生物相容性最差的材料是钢，钢释放的镍和铬量最大。金属离子仅在治疗的第一阶段从固定正畸矫治器中释放。建议对更多患者进行进一步的长期研究，以确定使用固定正畸矫治器的影响及其可能对组织产生的生物学效应。
