Amini F, Borzabadi Farahani A, Jafari A, Rabbani M
Department of Orthodontics and Dentofacial Orthopaedics, School of Dentistry, Islamic Azad Medical University, Tehran, Iran.
Orthod Craniofac Res. 2008 Feb;11(1):51-6. doi: 10.1111/j.1601-6343.2008.00414.x.
To compare the concentration of nickel, chromium and cobalt in oral mucosa cells of patients with and without fixed orthodontic appliances.
A total of 60 patients were included in this study. The control group consisted of 30 patients without any type of fixed orthodontic appliances or metal restoration in the mouth (20 females and 10 males from 16 to 20 years with a mean age of 18 years). The test group consisted of 30 patients who had fixed orthodontic appliance in their upper and lower arches (20 females and 10 male from 16 to 20 years with a mean age of 18.2 years). The metal content determinations were carried out using atomic absorption spectrophotometry with a graphite furnace.
According to spectrophotometric analysis, no significant differences in chromium (p = 0.09) and cobalt (p = 0.10) content of oral mucosa cells were found between the test and control samples. The nickel content in mucosa samples was significantly higher (p = 0.003) in orthodontic patients compared with the controls. The mean levels of nickel in control and orthodontic patient group were 12.26 and 21.74 ng / ml, respectively.
Our findings indicate that there was no difference in the concentration of chromium and cobalt in oral mucosa cells of patients with or without fixed appliances. However, a significantly higher concentration of nickel can be found in oral mucosa cells of patients wearing fixed orthodontic appliances. Continued follow-up is needed to determine the long-term significance of nickel release.
比较佩戴和未佩戴固定正畸矫治器患者口腔黏膜细胞中镍、铬和钴的浓度。
本研究共纳入60例患者。对照组由30例口腔内无任何类型固定正畸矫治器或金属修复体的患者组成（20例女性和10例男性，年龄16至20岁，平均年龄18岁）。试验组由30例上下牙弓均佩戴固定正畸矫治器的患者组成（20例女性和10例男性，年龄16至20岁，平均年龄18.2岁）。使用带石墨炉的原子吸收分光光度法进行金属含量测定。
根据分光光度分析，试验组和对照组样本的口腔黏膜细胞中铬（p = 0.09）和钴（p = 0.10）含量无显著差异。与对照组相比，正畸患者黏膜样本中的镍含量显著更高（p = 0.003）。对照组和正畸患者组的镍平均水平分别为12.26和21.74 ng/ml。
我们的研究结果表明，佩戴或未佩戴固定矫治器患者的口腔黏膜细胞中铬和钴的浓度没有差异。然而，佩戴固定正畸矫治器患者的口腔黏膜细胞中镍浓度显著更高。需要持续随访以确定镍释放的长期影响。
