van der Werf-Messing B H, van Putten W L
Dr. Daniel den Hoed Kliniek & Rotterdamsch Radio-Therapeutisch Instituut, The Netherlands.
Int J Radiat Oncol Biol Phys. 1989 Feb;16(2):369-71. doi: 10.1016/0360-3016(89)90332-5.
Forty-eight bladder cancers T2NXM0 with bad prognostic factors and 42 T3NXM0 growths, suitable for interstitial treatment, were submitted to 40 Gy external irradiation immediately followed by Cae137 Implant at "reduced dose". Intercurrent death corrected 5-year survival for both groups was about 80%. The influence of previously identified bad prognosticators (more than one TUR, WHO grade 3, 4, vascular invasion in the biopsy specimen, pathological IVP) was nearly eradicated.
48例具有不良预后因素的膀胱T2NXM0期癌和42例适合间质治疗的T3NXM0期肿瘤，先接受40Gy外照射，随后立即给予“低剂量”的铯137植入。两组的并发死亡校正5年生存率约为80%。先前确定的不良预后因素（不止一次经尿道切除术、世界卫生组织3级、4级、活检标本中的血管侵犯、病理静脉肾盂造影）的影响几乎被消除。
