Department of Applied Chemistry, ‡Education Center for Global Leaders in Molecular Systems for Devices, and §International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University , Fukuoka 819-0395, Japan.
Langmuir. 2017 Dec 19;33(50):14332-14339. doi: 10.1021/acs.langmuir.7b03427. Epub 2017 Dec 6.
Poly(vinyl ether), with short oxyethylene side chains which possess a simple and relatively polar structure, should be a unique candidate for a bioinert material thanks to its solubility in water. On the basis of living cationic copolymerization and subsequent ultraviolet light irradiation, thin films of poly(2-methoxyethyl vinyl ether) with different cross-linking densities were prepared on solid substrates. The films were thickened in water, and the extent was dependent on the cross-linking density. Although the surface chemistry and aggregation states were almost identical to one another, the stiffness, or the softness, of the outermost region in the film was strongly dependent on the cross-linking density. That is, the interface between polymer and water became thicker, or more diffused, with decreasing cross-linking density. The blood compatibility based on the platelet adhesion on to the hydrogel films was better for a more diffused interface.
聚（乙烯醚），具有短的氧亚乙基侧链，具有简单且相对极性的结构，由于其在水中的溶解度，应该是生物惰性材料的独特候选物。基于活性阳离子共聚和随后的紫外光照射，在固体基底上制备了具有不同交联密度的聚（2-甲氧基乙基乙烯基醚）薄膜。这些薄膜在水中增厚，并且增厚的程度取决于交联密度。尽管表面化学和聚集状态几乎相同，但薄膜的最外层区域的刚性或柔软性强烈依赖于交联密度。也就是说，随着交联密度的降低，聚合物和水之间的界面变得更厚或更扩散。基于血小板黏附在水凝胶膜上的血液相容性，更扩散的界面具有更好的血液相容性。
