aDepartment of Oncology, Wayne State University School of MedicinebKarmanos Cancer Institute, Detroit, Michigan, USA.
Curr Opin Hematol. 2018 Jan;25(1):3-6. doi: 10.1097/MOH.0000000000000392.
Green cytoplasmic inclusions in neutrophils are an uncommon finding on the peripheral blood smear. A comprehensive review of the literature is presented here with the goal of summarizing knowledge to date and increasing awareness.
A total of 41 cases have been reported in the literature, indicating the rarity of these green neutrophilic inclusions. Clinically, the inclusions have most consistently been associated with elevated transaminases, hepatic failure, and a high early mortality rate. The precise composition of the inclusions has not been confirmed.
Clinicians, hematologists, and laboratory technicians should be educated and have a high level of awareness of green neutrophilic inclusions. A more comprehensive analysis of a larger number of cases will be needed to clarify the true prevalence, associated conditions, biochemical nature, and clinical significance of this unusual finding.
中性粒细胞胞质内绿色包涵体在外周血涂片中不常见。本文对相关文献进行了全面回顾，旨在总结目前的认识并提高认识。
文献中总共报道了 41 例，表明这些绿色中性粒细胞包涵体非常罕见。临床上，这些包涵体最常与转氨酶升高、肝衰竭和早期高死亡率相关。包涵体的确切成分尚未得到证实。
临床医生、血液科医生和实验室技术人员应接受教育，对绿色中性粒细胞包涵体有较高的认识。需要更全面地分析更多的病例，以阐明这种不寻常发现的真实流行率、相关情况、生化性质和临床意义。
