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一名患有吸入性肺炎和肠穿孔患者的绿色细胞质嗜中性包涵体

Green Cytoplasmic Neutrophilic Inclusion Bodies in a Patient With Aspiration Pneumonia and Bowel Perforation.

作者信息

Wozniak Phillip S, Rampon Garrett L

机构信息

Department of Pediatrics, Children's Mercy Kansas City, Kansas City, USA.

Department of Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.

出版信息

Cureus. 2023 Jul 3;15(7):e41318. doi: 10.7759/cureus.41318. eCollection 2023 Jul.

DOI:10.7759/cureus.41318
PMID:37539398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10395657/
Abstract

Blue-green cytoplasmic neutrophilic inclusion bodies, previously described as "green crystals of death," are a rare but likely underreported finding in critically ill patients. This finding is associated with high mortality, ranging from 31% to 100% in published case studies. These inclusion bodies have been most strongly associated with acute liver injury and lactic acidosis, but they have also been reported in critically ill patients secondary to other etiologies. Here, we report a case of blue-green neutrophilic inclusion bodies in a patient with aspiration pneumonia and severe pneumoperitoneum secondary to bowel perforation. These blue-green neutrophilic inclusion bodies offer high prognostic value for physicians, and their presence should be considered a "critical result," indicating the severity of the patient's illness.

摘要

蓝绿色胞质嗜中性包涵体,以前被描述为“死亡的绿色晶体”,在重症患者中是一种罕见但可能未被充分报道的发现。这一发现与高死亡率相关,在已发表的病例研究中,死亡率从31%到100%不等。这些包涵体与急性肝损伤和乳酸性酸中毒的关联最为密切,但也有报道称在其他病因导致的重症患者中出现。在此,我们报告一例因误吸性肺炎和肠穿孔继发严重气腹的患者出现蓝绿色嗜中性包涵体的病例。这些蓝绿色嗜中性包涵体对医生具有很高的预后价值,它们的存在应被视为一个“关键结果”,表明患者病情的严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/84ae238be081/cureus-0015-00000041318-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/c650be469d15/cureus-0015-00000041318-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/f6832ac254e3/cureus-0015-00000041318-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/84ae238be081/cureus-0015-00000041318-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/c650be469d15/cureus-0015-00000041318-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/f6832ac254e3/cureus-0015-00000041318-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7089/10395657/84ae238be081/cureus-0015-00000041318-i03.jpg

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Green Cytoplasmic Neutrophilic Inclusion Bodies in a Patient With Aspiration Pneumonia and Bowel Perforation.一名患有吸入性肺炎和肠穿孔患者的绿色细胞质嗜中性包涵体
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本文引用的文献

1
Green Neutrophilic Inclusion Bodies: a Rare Phenomenon Indicating a More Critical Situation for Patients.绿色中性粒细胞包涵体:一种罕见的现象,表明患者情况更为危急。
Clin Lab. 2022 Sep 1;68(9). doi: 10.7754/Clin.Lab.2021.211146.
2
Neutrophils with bright green inclusions in a patient with chest pain.一名胸痛患者的中性粒细胞含有亮绿色包涵体。
Int J Lab Hematol. 2022 Dec;44(6):1019-1020. doi: 10.1111/ijlh.13939. Epub 2022 Jul 24.
3
Blue-green cytoplasmic inclusions in neutrophils/monocytes of patients with yellow fever.黄热病患者中性粒细胞/单核细胞中的蓝绿色胞质内含物。
Int J Lab Hematol. 2022 Aug;44(4):e168-e171. doi: 10.1111/ijlh.13827. Epub 2022 Mar 15.
4
Green neutrophilic inclusions in meningococcal sepsis.脑膜炎球菌败血症中的绿色嗜中性粒细胞包涵体。
Int J Lab Hematol. 2021 Apr;43(2):e95-e96. doi: 10.1111/ijlh.13422. Epub 2020 Dec 8.
5
Clinical significance of blue-green neutrophil and monocyte cytoplasmic inclusions in SARS-CoV-2 positive critically ill patients.新型冠状病毒肺炎(SARS-CoV-2)阳性重症患者中蓝绿色中性粒细胞和单核细胞胞质内包涵体的临床意义
Br J Haematol. 2020 Jul;190(2):e89-e92. doi: 10.1111/bjh.16882. Epub 2020 Jun 13.
6
Blue-green neutrophilic inclusion bodies in the critically ill patient.危重症患者体内的蓝绿色嗜中性包涵体。
Clin Case Rep. 2019 May 16;7(6):1249-1252. doi: 10.1002/ccr3.2196. eCollection 2019 Jun.
7
An unanticipated finding on peripheral smear: Blue-green crystals of impeding death?外周血涂片上的意外发现:濒死的蓝绿色结晶?
Am J Hematol. 2019 Jun;94(6):733-734. doi: 10.1002/ajh.25286. Epub 2018 Oct 15.
8
Green neutrophilic inclusions: current understanding and review of literature.绿色中性粒细胞包涵体:当前的认识和文献复习。
Curr Opin Hematol. 2018 Jan;25(1):3-6. doi: 10.1097/MOH.0000000000000392.
9
Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality.中性粒细胞和单核细胞中的绿色包涵体是急性肝损伤和高死亡率的一个指标。
Acta Haematol. 2017;138(2):85-90. doi: 10.1159/000477794. Epub 2017 Aug 17.
10
Green Neutrophilic Inclusions and Acute Hepatic Failure: Clinical Significance and Brief Review of the Literature.绿色嗜中性粒细胞包涵体与急性肝衰竭:临床意义及文献简要综述
Ann Clin Lab Sci. 2017 Jan;47(1):58-61.