Sheth U, Wasserstein D, Jenkinson R, Moineddin R, Kreder H, Jaglal S
University of Toronto, 160-500 University Avenue, Toronto, Ontario, M5G 1V7, Canada.
University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room MG323, Toronto, Ontario, M4N 3M5, Canada.
Bone Joint J. 2017 Dec;99-B(12):1629-1636. doi: 10.1302/0301-620X.99B12.BJJ-2017-0465.R1.
To determine whether the findings from a landmark Canadian trial assessing the optimal management of acute rupture of the Achilles tendon influenced the practice patterns of orthopaedic surgeons in Ontario, Canada.
Health administrative databases were used to identify Ontario residents ≥ 18 years of age with an Achilles tendon rupture from April 2002 to March 2014. The rate of surgical repair (per 100 cases) was calculated for each calendar quarter. A time-series analysis was used to determine whether changes in the rate were chronologically related to the dissemination of results from a landmark trial published in February 2009. Non-linear spline regression was then used independently to identify critical time-points of change in the surgical repair rate to confirm the findings.
A total of 29 531 patients sustained an Achilles tendon rupture during the study period. Consistently, around 21 out of every 100 cases underwent surgical repair up to the first quarter of 2010. However, by the first quarter of 2014, only 6.5 cases per 100 had surgery. A statistically significant decrease in the rate of surgical repair was observed within one year of the presentation of landmark trial results in 2009 (p < 0.001). July 2009 was independently identified as a critical time at which the surgical repair rate began to significantly decline (p < 0.001). The dissemination of trial results was associated with a significant drop in the rate of surgical repair at non-teaching hospitals (p = 0.001).
The current study demonstrates that large, well-designed randomised trials, have the potential to encourage significant changes in the practice patterns of orthopaedic surgeons. Cite this article: 2017;99-B:1629-36.
确定一项具有里程碑意义的加拿大试验中关于评估跟腱急性断裂最佳治疗方法的研究结果是否影响了加拿大安大略省骨科医生的临床实践模式。
利用卫生行政数据库识别出2002年4月至2014年3月期间安大略省18岁及以上的跟腱断裂居民。计算每个日历季度的手术修复率(每100例)。采用时间序列分析来确定该比率的变化是否与2009年2月发表的一项具有里程碑意义的试验结果的传播在时间上相关。然后独立使用非线性样条回归来确定手术修复率变化的关键时间点,以证实研究结果。
在研究期间,共有29531例患者发生跟腱断裂。一直以来,在2010年第一季度之前,每100例中约有21例接受了手术修复。然而,到2014年第一季度,每100例中只有6.5例接受了手术。在2009年具有里程碑意义的试验结果公布后的一年内,观察到手术修复率有统计学意义的下降(p<0.001)。2009年7月被独立确定为手术修复率开始显著下降的关键时间点(p<0.001)。试验结果的传播与非教学医院手术修复率的显著下降相关(p = 0.001)。
当前研究表明,大型、设计良好的随机试验有可能促使骨科医生的临床实践模式发生重大改变。引用本文:2017;99-B:1629 - 36。