Osman Huda A, Al-Jurayyan Nasir A M, Babiker Amir M I, Al-Otaibi Hessah M N, AlKhalifah Reem D H, Al Issa Sharifah D A, Mohamed Sarar
Department of Pediatrics, College of Medicine, King Saud University Medical City, (KSUMC), King Saud University, Riyadh, Saudi Arabia.
Department of Pediatrics, King Abdullah Specialized Children's Hospital and King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Sudan J Paediatr. 2017;17(1):19-24.
Precocious puberty is a developmental process that gives rise to secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. In general, precocious puberty can be classified as central or peripheral. This is a retrospective hospital-based study was conducted at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia, during the period January 1990 and December 2016. Data were abstracted from the medical records of patients diagnosed with precocious puberty, with special emphasis on age, sex, clinical characteristics, and relevant hormonal assay. A total of 62 patients were diagnosed with Precocious Puberty (PP); 43 had Central Precocious Puberty (CPP) while 19 had peripheral precocious puberty (PPP). The majority of girls with CPP (68%) had idiopathic PP, while pathological causes were found in (50%) of boys. The commonest cause of PPP was congenital adrenal hyperplasia (42%) and chronic hypothyroidism (26%). In conclusion, this study showed that precocious Puberty is a common endocrine problem in our center. The etiology of CPP was idiopathic in the majority of girls while it was caused by CNS pathology in most of the boys in this cohort. Peripheral precocious puberty is not that rare and mainly caused by congenital adrenal hyperplasia or hypothyroidism.
性早熟是一种发育过程，在女孩8岁前、男孩9岁前出现第二性征。一般来说，性早熟可分为中枢性或外周性。这是一项基于医院的回顾性研究，于1990年1月至2016年12月在沙特阿拉伯利雅得的哈立德国王大学医院（KKUH）进行。数据从诊断为性早熟的患者病历中提取，特别关注年龄、性别、临床特征和相关激素检测。共有62例患者被诊断为性早熟（PP）；43例为中枢性性早熟（CPP），19例为外周性性早熟（PPP）。大多数CPP女孩（68%）患有特发性性早熟，而在男孩中发现病理性原因的占（50%）。PPP最常见的原因是先天性肾上腺增生（42%）和慢性甲状腺功能减退（26%）。总之，本研究表明性早熟在我们中心是一个常见的内分泌问题。该队列中大多数女孩CPP的病因是特发性的，而大多数男孩是由中枢神经系统病变引起的。外周性性早熟并不罕见，主要由先天性肾上腺增生或甲状腺功能减退引起。
