Jakubowska Anna, Grajewska-Ferens Magdalena, Brzewski Michał, Sopyło Barbara
Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland.
Pol J Radiol. 2011 Oct;76(4):21-7.
Precocious puberty (PP) is defined as the appearance of symptoms of puberty in girls before 8 years of age and in boys under 9. Statistically, it occurs much more frequently in girls, while it is a rare pathology in boys.
MATERIAL/METHODS: Over the period of 10 years, between 1999 and 2009, 39 girls and 17 boys aged 18 months - 9 years were diagnosed with precocious puberty,, and treated at the Endocrinology Clinic. THE FOLLOWING TESTS WERE PERFORMED IN ALL CHILDREN: physical and anthropometric examinations, abdominal ultrasound scan (US) with evaluation of adrenal glands, examination of testes in boys or breasts and pelvic organs in girls, evaluation of skeletal age and, in selected cases, CT scans of the abdomen, MRI of the CNS, and hormonal laboratory tests.
In the group of 17 boys the findings included: gonadotropin -dependent central puberty in 6 boys: idiopathic in 5 cases, and 1 case of a brain tumor - astrocytoma. Gonadotropin-independent precocious pseudopuberty was diagnosed in 11 boys: congenital adrenal hyperplasia in 5; in 1case - hyperandrogenism caused by overactivity of 5-α reductase; in 2 subjects - adrenal adenoma; in 2 boys adrenocortical carcinoma was diagnosed and Leydig cell tumor of testis in 1.
性早熟（PP）的定义为女孩在8岁前、男孩在9岁前出现青春期症状。从统计学角度来看，性早熟在女孩中更为常见，而在男孩中则是一种罕见的病症。
材料/方法：在1999年至2009年的10年期间，39名年龄在18个月至9岁的女孩和17名男孩被诊断为性早熟，并在内分泌诊所接受治疗。所有儿童均进行了以下检查：体格检查和人体测量、肾上腺评估的腹部超声扫描（US）、男孩的睾丸检查或女孩的乳房及盆腔器官检查、骨龄评估，以及在某些特定病例中进行腹部CT扫描、中枢神经系统MRI检查和激素实验室检测。
在17名男孩中，检查结果如下：6名男孩为促性腺激素依赖性中枢性性早熟：5例为特发性，1例由脑肿瘤——星形细胞瘤引起。11名男孩被诊断为促性腺激素非依赖性性早熟假性青春期：5例为先天性肾上腺皮质增生；1例为5-α还原酶活性过高导致的高雄激素血症；2例为肾上腺腺瘤；2名男孩被诊断为肾上腺皮质癌，1名男孩患有睾丸间质细胞瘤。
