阿尔茨海默病患者的简易精神状态检查及后扣带回质子波谱分析

Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease.

作者信息

Lee Hae Won, Caramelli Paulo, Otaduy Maria Concepcion Garcia, Nitrini Ricardo, Leite Claudia da Costa

机构信息

Department of Radiology, University of São Paulo School of Medicine.

Department of Neurology, University of São Paulo School of Medicine and Department of Internal Medicine, University Federal of Minas Gerais, Belo Horizonte.

出版信息

Dement Neuropsychol. 2007 Jul-Sep;1(3):248-252. doi: 10.1590/S1980-57642008DN10300005.

DOI:10.1590/S1980-57642008DN10300005

PMID:29213397

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5619002/

Abstract

UNLABELLED

To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls.

METHODS

We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface).

RESULTS

Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores.

CONCLUSION

The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.

摘要

未标注

比较轻度或中度阿尔茨海默病患者及对照组后扣带回中的代谢物比率与简易精神状态检查表（MMSE）测试得分。

方法

我们通过质子光谱法对29例轻度或中度阿尔茨海默病患者及15名对照者进行评估，体素位于后扣带回。对所有患者和对照者应用MMSE。获得代谢物比率：N-乙酰天门冬氨酸/肌酸（Naa/Cr）、肌醇/肌酸（mI/Cr）和肌醇/N-乙酰天门冬氨酸（mI/Naa），然后使用MRUI软件（磁共振用户界面）进行后处理。