Baptista Maria Alice Tourinho, Santos Raquel Luiza, Kimura Nathália, Lacerda Isabel Barbeito, Dourado Marcia Cristina Nascimento
MSc, Center for Alzheimer's disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, RJ, Brazil.
PhD, Center for Alzheimer's disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Dement Neuropsychol. 2017 Jul-Sep;11(3):308-311. doi: 10.1590/1980-57642016dn11-030015.
Studies report that people with young onset Alzheimer's disease (YOAD) have higher levels of disease awareness compared to those with late onset AD. We report a case of a man with YOAD who had preserved awareness of disease, depression and risk of suicide associated with the development of the dementia. Cognitive functioning, disease severity, depressive symptoms and awareness of disease were assessed using validated measures. The person with YOAD showed a moderate level of disease severity and high degree of dependence for activities of daily living. There was recognition of memory problems and routine changes with presence of intense pessimism, low self-esteem and suicidal ideation. This case points to the existence of specific issues related to young onset dementia and the clinical importance of identifying and treating patients who might be aware of their condition.
研究报告称，早发性阿尔茨海默病（YOAD）患者比晚发性阿尔茨海默病患者对疾病的认知水平更高。我们报告了一例早发性阿尔茨海默病男性患者，其对疾病、抑郁以及与痴呆症发展相关的自杀风险保持着认知。使用经过验证的测量方法对认知功能、疾病严重程度、抑郁症状和疾病认知进行了评估。该早发性阿尔茨海默病患者表现出中等程度的疾病严重程度和对日常生活活动的高度依赖。患者认识到记忆问题和日常变化，同时存在强烈的悲观情绪、低自尊和自杀观念。该病例表明存在与早发性痴呆相关的特定问题，以及识别和治疗可能意识到自身病情的患者的临床重要性。
