智力需求和正规教育作为阿尔茨海默病的认知保护因素。 不过你原文中“Intelectual”拼写有误，正确的是“Intellectual” 。
Intelectual demand and formal education as cognitive protection factors in Alzheimer's disease.
作者信息
Wajman José Roberto, Bertolucci Paulo Henrique Ferreira F
机构信息
Neuropsychologist, Behavioral Neurology Section. Behavioral Neurology Section, Department of Neurology asnd Neurosurgery, Escola Paulista de Medicina, UNIFESP.
Neurologist, Behavioral Neurology Section, Department of Neurology and Neurosurgery, Escola Paulista de Medicina, UNIFESP.
出版信息
Dement Neuropsychol. 2010 Oct-Dec;4(4):320-324. doi: 10.1590/S1980-57642010DN40400011.
UNLABELLED
To investigate the possible association between educational level and previous professional occupation, and objective cognitive and functional evaluation in a sample of elderly patients with Alzheimer's disease.
METHODS
Through retrospective analysis of medical files, 174 patients with probable Alzheimer disease were randomly selected, classified and submitted to analysis according to previous professional occupation and years of formal education.
RESULTS
Subjects with lower education and less intellectually-demanding occupations performed worse than higher educated subjects in all cognitive subtests and on the functional scale.
CONCLUSIONS
Results indicate that not only the total years of education, but also professional occupation has an impact on cognition and functioning in accordance with the hypothesis of cognitive reserve. Our findings confirmed this hypothesis, where subjects with higher education/ higher intellectual demand manifested first symptoms later than low education/ low intellectual demand subjects, with the latter group also exhibiting faster disease progression.
未标注
为了研究老年阿尔茨海默病患者样本中教育水平与既往职业之间可能存在的关联，以及客观认知和功能评估。
方法
通过对病历的回顾性分析，随机选取174例可能患有阿尔茨海默病的患者，根据既往职业和正规教育年限进行分类并进行分析。
结果
在所有认知子测试和功能量表上，受教育程度较低且职业智力要求较低的受试者表现比受教育程度较高的受试者差。
结论
结果表明，不仅教育总年限，而且职业也会根据认知储备假说对认知和功能产生影响。我们的研究结果证实了这一假说，即受教育程度较高/智力需求较高的受试者比受教育程度较低/智力需求较低的受试者出现首发症状的时间更晚，后一组患者的疾病进展也更快。
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