端粒长度与氯乙烯单体接触中国工人染色体损伤的关联。
Association of Telomere Length With Chromosomal Damage Among Chinese Workers Exposed to Vinyl Chloride Monomer.
机构信息
Department of Occupational Health and Toxicology, School of Public Health, Fudan University, and Key Laboratory of Public Health and Safety of Ministry of Education of China, Shanghai (Mr Zheng, Dr Zhang, Mr Xu, Mr Wang, Dr Yu, Mr Zhang, Mr Huang, Dr Xia), School of Public Health, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, He'nan (Mr Zhang), Minhang District Center for Disease Control and Prevention, Shanghai, China (Mr Xu, Mr Wang), School of Public Health, University of Illinois, Chicago, Illinois (Dr Li, Dr Brandt-Rauf).
出版信息
J Occup Environ Med. 2017 Dec;59(12):e252-e256. doi: 10.1097/JOM.0000000000001177.
OBJECTIVE
To explore the relationship between relative telomere length (RTL) and chromosomal damage represented by micronucleus (MN) frequencies among vinyl chloride monomer (VCM) -exposed workers.
METHODS
A group of 126 VCM-exposed workers, 60 internal controls, and 25 external controls were examined for RTL by Quantitative polymerase chain reaction and MN frequencies by cytokinesis-block micronucleus test. Cumulative exposure dose was used to estimate the exposure of VCM-exposed workers.
RESULTS
The RTL were significantly shorter in exposed workers and internal controls than in external controls. The exposed workers had significantly increased MN frequencies than both control groups. Additionally, MN frequencies were negatively associated with RTL in VCM-exposed group.
CONCLUSIONS
VCM exposure may alter telomere length, which could be a potential biomarker of susceptibility to chromosomal damage.
目的
探讨氯乙烯单体（VCM）暴露工人的相对端粒长度（RTL）与微核（MN）频率所代表的染色体损伤之间的关系。
方法
采用定量聚合酶链反应检测 126 名 VCM 暴露工人、60 名内部对照和 25 名外部对照的 RTL，采用胞质分裂阻断微核试验检测 MN 频率。累积暴露剂量用于估计 VCM 暴露工人的暴露情况。
结果
暴露组和内对照组的 RTL 明显短于外对照组。暴露组 MN 频率明显高于两组对照组。此外，VCM 暴露组 MN 频率与 RTL 呈负相关。
结论
VCM 暴露可能会改变端粒长度，这可能是染色体损伤易感性的潜在生物标志物。
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