硬质合金生产工人的癌症发病率：瑞典队列研究。
Cancer Incidence Among Hardmetal Production Workers: The Swedish Cohort.
机构信息
Department of Medical Science, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden (Dr Svartengren); Department of Occupational and Environmental Medicine, Faculty of Science, Örebro University, Örebro, Sweden (Ms Bryngelsson, Dr Westberg); Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania (Drs Marsh, Buchanich, Ms Zimmerman); and Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois (Ms Kennedy, Dr Esmen).
出版信息
J Occup Environ Med. 2017 Dec;59(12):e365-e373. doi: 10.1097/JOM.0000000000001185.
: The cancer incidence was determined for 3713 workers from three plants from 1958 to 2011. The exposure measures were ever/never exposed, duration, cumulative, and mean cobalt concentrations.The incidence of all malignant neoplasms was increased at one plant, but standardized incidence ratio (SIR) was 0.96 for all workers. Lung cancer incidence was increased for all workers, SIR 1.38 (1.01 to 1.85). The lung cancer incidence was associated with shorter employment time and showed no exposure-response. There was decreased incidence for skin cancer. Increased lip cancer incidence found at one of the production plants might be related to diagnostic intensity.Lung cancer incidence showed no correlation to cobalt exposure based on internal comparison. The increased SIR for all workers might be associated with other factors.
自 1958 年至 2011 年，对来自三家工厂的 3713 名工人的癌症发病率进行了测定。暴露测量包括曾经/从未暴露、持续时间、累积和平均钴浓度。一家工厂的所有恶性肿瘤发病率均有所上升，但所有工人的标准化发病比（SIR）为 0.96。所有工人的肺癌发病率均有所上升，SIR 为 1.38（1.01 至 1.85）。肺癌发病率与较短的就业时间有关，且不存在暴露反应关系。皮肤癌的发病率有所下降。在其中一个生产工厂，唇癌的发病率有所上升，这可能与诊断强度有关。基于内部比较，未发现肺癌发病率与钴暴露有关。所有工人的 SIR 升高可能与其他因素有关。
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