University of Cincinnati College of Medicine, 3230 Eden Avenue, Cincinnati, OH 45267-0552, USA.
Rev Neurosci. 2018 Jun 27;29(4):369-376. doi: 10.1515/revneuro-2017-0060.
Calcitonin gene-related peptide (CGRP) is a neuropeptide that has an important anti-inflammatory role in the immune system. Research has shown that CGRP is an integral part in peripheral nerve regeneration by (1) suppressing tumor necrosis factor-α, (2) forming an initial nerve bridge by increasing fibroblast motility and extracellular matrix synthesis, (3) vascularizing the spinal cord injury site, and (4) inducing Schwann cell (SC) proliferation. In this treatise, the following hypotheses will be explored: (1) CGRP is induced by c-Jun to regulate SC dedifferentiation, (2) CGRP promotes the chemotaxic migration of SCs along the nerve bridge, and (3) CGRP induces myelinophagy by activating various signaling pathways, such as p38 mitogen-activated protein kinase and Raf/extracellular signal-regulated kinase. These processes provide a framework for understanding the role of CGRP in peripheral nerve regeneration, which may be important in developing better strategies for nerve repair and gaining further insight into demyelinating diseases.
降钙素基因相关肽（CGRP）是一种神经肽，在免疫系统中具有重要的抗炎作用。研究表明，CGRP 通过以下方式成为周围神经再生的重要组成部分：（1）抑制肿瘤坏死因子-α；（2）通过增加成纤维细胞迁移和细胞外基质合成形成初始神经桥；（3）使脊髓损伤部位血管化；（4）诱导雪旺细胞（SC）增殖。在本论文中，将探讨以下假设：（1）CGRP 由 c-Jun 诱导以调节 SC 去分化；（2）CGRP 促进 SC 沿着神经桥的趋化迁移；（3）CGRP 通过激活各种信号通路（如 p38 丝裂原活化蛋白激酶和 Raf/细胞外信号调节激酶）诱导髓鞘吞噬作用。这些过程为理解 CGRP 在周围神经再生中的作用提供了框架，这对于开发更好的神经修复策略以及更深入地了解脱髓鞘疾病可能很重要。
