The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.
作者信息
Cardarelli Ross A, Jones Karen, Pisella Lucie I, Wobst Heike J, McWilliams Lisa J, Sharpe Paul M, Burnham Matthew P, Baker David J, Chudotvorova Ilona, Guyot Justine, Silayeva Liliya, Morrow Danielle H, Dekker Niek, Zicha Stephen, Davies Paul A, Holenz Jörg, Duggan Mark E, Dunlop John, Mather Robert J, Wang Qi, Medina Igor, Brandon Nicholas J, Deeb Tarek Z, Moss Stephen J
机构信息
AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.
Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.
出版信息
Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442.
Abstract
摘要
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The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.小分子CLP257不会改变钾氯协同转运体KCC2的活性，但会增强GABA受体的活性。
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Reply to The small molecule CLP257 does not modify activity of the K-Cl co-transporter KCC2 but does potentiate GABA receptor activity.对小分子CLP257不改变钾氯共转运体KCC2的活性但能增强GABA受体活性的回应。
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本文引用的文献
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Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.控制 KCC2：癫痫治疗的新靶点。
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