Zhang Beibei, Wang Lifu, Liu Jiahua, Xu Lian, Song Langui, Wu Xiaoying, Sun Xi, Wu Zhongdao
Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Key Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, Guangdong, China.
PLoS Negl Trop Dis. 2017 Dec 7;11(12):e0006016. doi: 10.1371/journal.pntd.0006016. eCollection 2017 Dec.
Telmatoscopus albipunctatus, a cosmopolitan fly, is widely distributed throughout moist environments. It is one of the most medically important insects (especially in urban environments) that may potentially cause myiasis. Urinary myiasis and other sites of infestation, including the intestine, nasal passages, lung, and derma, have been reported. This is the first case report of a Chinese middlescent woman infected with T. albipunctatus in Guangzhou, China. In the present report, a 50-year-old woman came to The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, because larvae were found when urinating in the morning; this had occurred every two days within the past two months. She complained of frequent micturition and urgency. Urine tests indicated that all indexes were normal except for slight urinary tract infection. Subsequently, the larvae were sent to the diagnostic section for parasitic infection in the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. The stereoscopic microscope and transmission electron microscope were used for morphological observation. On this basis, the cytochrome oxidase subunit 1 (COX1) gene was specifically amplified by PCR. Sequence analysis of the PCR product and phylogenetic analysis were used to identify the species. Morphological analysis combined with molecular biology methods indicated that the insect was the fourth instar larvae of T. albipunctatus. Our results show that this was a case of a 50-year-old woman infected with T. albipunctatus larvae in her urinary tract, and the findings suggest that clinicians should be vigilant for this infection.
白点厕蝇是一种世界性分布的苍蝇，广泛分布于潮湿环境中。它是最重要的医学昆虫之一（尤其是在城市环境中），有可能导致蝇蛆病。已报告有泌尿道蝇蛆病及其他感染部位，包括肠道、鼻腔、肺部和皮肤。这是中国广州首例有报道的中年女性感染白点厕蝇的病例。在本报告中，一名50岁女性前往中国广州南方医科大学第三附属医院就诊，原因是她在早晨排尿时发现有幼虫；在过去两个月里，这种情况每两天就会出现一次。她主诉尿频和尿急。尿液检查表明，除了轻微尿路感染外，所有指标均正常。随后，这些幼虫被送往中国广州中山大学中山医学院寄生虫学系寄生虫感染诊断科。使用体视显微镜和透射电子显微镜进行形态学观察。在此基础上，通过PCR特异性扩增细胞色素氧化酶亚基1（COX1）基因。对PCR产物进行序列分析并进行系统发育分析以鉴定物种。形态学分析与分子生物学方法相结合表明，该昆虫为白点厕蝇的四龄幼虫。我们的结果表明，这是一例50岁女性泌尿道感染白点厕蝇幼虫的病例，研究结果提示临床医生应对这种感染保持警惕。
