a Department of Periodontology , Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo , Oslo , Norway.
b Northern State Medical University , Arkhangelsk , Russian Federation.
Acta Odontol Scand. 2018 May;76(4):241-246. doi: 10.1080/00016357.2017.1412499. Epub 2017 Dec 7.
A commercially available mouth rinse with ethyl lauroyl arginate and essential oils claims to have better antimicrobial properties than the traditional essential oil products. The aim of this study was to compare the plaque and gingivitis inhibiting effect of the commercial product containing essential oils with ethyl lauroyl arginate with one placebo and one negative control in a modified experimental gingivitis model.
In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21 d, simultaneously treated with the commercial test solution, 21.6% hydro-alcohol solution and sterile water, respectively. The maxillary right quadrant of each individual received mouthwash only, whereas the maxillary left quadrant was subject to both rinsing and mechanical oral hygiene. Compliance and side effects were monitored at d 7, 14, and 21. Plaque and gingivitis scores were obtained at baseline and d 21.
Although the commercial product containing essential oils with ethyl lauroyl arginate performed statistically significantly better regarding average plaque scores on all surfaces combined than the placebo (p = .018) and negative control (p = .003) when no mechanical tooth cleaning was performed, the product still left the patient with enough plaque to cause gingivitis and thus seemed of questionable clinical benefit to the patient. ClinicalTrials.gov Identifier is NCT02884817.
一种市售的含月桂酰精氨酸乙酯和精油的漱口液声称具有比传统精油产品更好的抗菌性能。本研究旨在比较含月桂酰精氨酸乙酯和精油的商业产品与安慰剂和阴性对照组在改良实验性龈炎模型中的菌斑和牙龈炎抑制效果。
在三组健康志愿者中，在 21 天内诱导并监测实验性龈炎，同时分别用商业测试溶液、21.6%的水醇溶液和无菌水进行治疗。每位个体的上颌右侧象限仅接受漱口液，而上颌左侧象限则同时进行漱口和机械口腔卫生。在第 7、14 和 21 天监测依从性和副作用。在基线和第 21 天获得菌斑和牙龈炎评分。
尽管含有月桂酰精氨酸乙酯和精油的商业产品在不进行机械牙齿清洁时，在所有联合表面的平均菌斑评分方面表现出统计学上优于安慰剂（p=0.018）和阴性对照组（p=0.003）的显著改善，但该产品仍使患者留有足够的菌斑引起牙龈炎，因此对患者的临床益处似乎值得怀疑。ClinicalTrials.gov 标识符为 NCT02884817。
