Department of Periodontology, Institute of Clinical Odontology, Faculty of Dentistry, University of Oslo , Norway.
Acta Odontol Scand. 2013 Nov;71(6):1613-9. doi: 10.3109/00016357.2013.782506. Epub 2013 May 3.
Studies have reported commercially available essential oils with convincing plaque and gingivitis preventing properties. However, no tests have compared these essential oils, i.e. Listerine(®), against their true vehicle controls.
To compare the plaque and gingivitis inhibiting effect of a commercially-available essential oil (Listerine(®) Total Care) to a negative (22% hydro-alcohol solution) and a positive (0.2% chlorhexidine (CHX)) control in an experimental gingivitis model.
In three groups of 15 healthy volunteers, experimental gingivitis was induced and monitored over 21 days, simultaneously treated with Listerine(®) Total Care (test), 22% hydro-alcohol solution (negative control) and 0.2% chlorhexidine solution (positive control), respectively. The upper right quadrant of each individual received mouthwash only, whereas the upper left quadrant was subject to both rinses and mechanical oral hygiene. Plaque, gingivitis and side-effects were assessed at day 7, 14 and 21.
After 21 days, the chlorhexidine group showed significantly lower average plaque and gingivitis scores than the Listerine(®) and alcohol groups, whereas there was little difference between the two latter.
Listerine(®) Total Care had no statistically significant effect on plaque formation as compared to its vehicle control.
已有研究报道称，市售的一些精油具有明显的抑制菌斑和牙龈炎的作用。然而，目前还没有试验将这些精油（如李施德林全效护理漱口水）与它们的真正载体对照物进行比较。
本试验旨在比较市售精油（李施德林全效护理漱口水）与阴性对照（22%酒精溶液）和阳性对照（0.2%洗必泰）在实验性牙龈炎模型中对菌斑和牙龈炎的抑制效果。
选择 15 名健康志愿者，随机分为 3 组，在 21 天的时间内，实验组采用李施德林全效护理漱口水（试验组）、22%酒精溶液（阴性对照组）和 0.2%洗必泰溶液（阳性对照组）漱口，同时采用机械性口腔卫生措施。仅对右上象限进行漱口，左上象限则接受漱口和机械性口腔卫生。分别于第 7、14 和 21 天评估菌斑、牙龈炎和不良反应。
21 天后，洗必泰组的平均菌斑和牙龈炎评分显著低于李施德林组和酒精组，而后两组之间则无明显差异。
与载体对照相比，李施德林全效护理漱口水对菌斑形成没有统计学意义上的显著影响。
