煤矿工人的铅暴露与氧化应激

Lead Exposure and Oxidative Stress in Coal Miners.

作者信息

Zimet Zlatko, Bilban Marjan, Fabjan Teja, Suhadolc Kristina, Poljšak Borut, Osredkar Joško

机构信息

National Institute of Public Health, Trubarjeva 2, 1000 Ljubljana, Slovenia.

Department of Public Health, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.

出版信息

Biomed Environ Sci. 2017 Nov;30(11):841-845. doi: 10.3967/bes2017.113.

DOI:10.3967/bes2017.113

PMID:29216962

Abstract

We aimed to investigate the short-term correlation between blood lead levels and oxidative stress generation in coal miners. The study involved 94 male coal miners from the Velenje Coal mine, arranged into four groups: three groups according to the number of consecutive working days, and a fourth control group. Miners who worked for three consecutive days had higher blood levels of lead and 8-isoprostane than the control group (P < 0.001). Correlation between lead and 8-isoprostane was of medium strength (r = 0.512, P < 0.001). Short-term lead environmental exposure can potentially harmful and should be considered when formulating improvements in working processes.

摘要

我们旨在研究煤矿工人血铅水平与氧化应激产生之间的短期相关性。该研究涉及来自韦莱涅煤矿的94名男性煤矿工人，分为四组：三组根据连续工作日数量划分，第四组为对照组。连续工作三天的矿工血铅和8-异前列腺素水平高于对照组（P < 0.001）。铅与8-异前列腺素之间的相关性为中等强度（r = 0.512，P < 0.001）。短期铅环境暴露可能具有潜在危害，在制定工作流程改进措施时应予以考虑。