Zimet Zlatko, Bilban Marjan, Marc Malovrh Mateja, Korošec Peter, Poljšak Borut, Osredkar Joško, Šilar Mira
National Institute of Public Health, Trubarjeva 2, 1000 Ljubljana, Slovenia.
Department of Public Health, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana Slovenia.
Biomed Environ Sci. 2016 Aug;29(8):589-593. doi: 10.3967/bes2016.078.
This study was to investigate whether working in conditions of elevated concentrations of mine gases (CO2, CO, CH4, DMS) and dust may result in oxidative stress. Coal miners (n=94) from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate (EBC). Miners who worked for three consecutive days had higher 8-isoprostane values in EBC compared to the control group. Gas/dust concentrations and exposure time of a single/two day shift seem too low to trigger immediate oxidative stress.
本研究旨在调查在矿井气体（二氧化碳、一氧化碳、甲烷、二甲基硫醚）和粉尘浓度升高的条件下工作是否会导致氧化应激。来自韦莱涅煤矿的94名煤矿工人，根据连续工作日的数量分为对照组和三组。将呼出气冷凝物（EBC）中的8-异前列腺素作为氧化应激的生物标志物进行测量。与对照组相比，连续工作三天的矿工EBC中的8-异前列腺素值更高。单日/双日轮班的气体/粉尘浓度和暴露时间似乎过低，无法立即引发氧化应激。
