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本文引用的文献

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Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma.PI3K通路失调与头颈部鳞状细胞癌的靶向治疗
Oncotarget. 2017 Mar 28;8(13):22203-22217. doi: 10.18632/oncotarget.14729.
2
Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma.内皮细胞和循环 C19MC microRNAs 是婴儿血管瘤的生物标志物。
JCI Insight. 2016 Sep 8;1(14):e88856. doi: 10.1172/jci.insight.88856.
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Genetic basis for vascular anomalies.血管异常的遗传基础。
Semin Cutan Med Surg. 2016 Sep;35(3):128-36. doi: 10.12788/j.sder.2016.051.
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Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis.肿瘤PIK3CA突变在结直肠癌中的预后作用：一项系统评价和荟萃分析。
Ann Oncol. 2016 Oct;27(10):1836-48. doi: 10.1093/annonc/mdw264. Epub 2016 Jul 19.
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Molecular pathological classification of colorectal cancer.结直肠癌的分子病理分类
Virchows Arch. 2016 Aug;469(2):125-34. doi: 10.1007/s00428-016-1956-3. Epub 2016 Jun 20.
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Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies.西罗莫司治疗复杂血管异常的疗效与安全性。
Pediatrics. 2016 Feb;137(2):e20153257. doi: 10.1542/peds.2015-3257. Epub 2016 Jan 18.
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Changing indications for invasive testing in an era of improved screening.在筛查水平提高的时代，侵入性检测的适应症不断变化。
Semin Perinatol. 2016 Feb;40(1):56-66. doi: 10.1053/j.semperi.2015.11.008. Epub 2015 Dec 24.
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Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming, and long non-coding RNAs.转座元件处于胚胎发生、胚胎干细胞、重编程和长链非编码RNA之间的交叉路口中心。
Sci Bull (Beijing). 2015;60(20):1722-1733. doi: 10.1007/s11434-015-0905-x. Epub 2015 Oct 13.
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Spreading the word: non-autonomous effects of apoptosis during development, regeneration and disease.广而告之：细胞凋亡在发育、再生和疾病过程中的非自主效应
Development. 2015 Oct 1;142(19):3253-62. doi: 10.1242/dev.127878.
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The Lymphatic Malformation Function (LMF) Instrument.淋巴管畸形功能（LMF）器械
Otolaryngol Head Neck Surg. 2015 Oct;153(4):656-62. doi: 10.1177/0194599815594776. Epub 2015 Jul 20.

头颈部淋巴管畸形认识的新前沿：自然史与基础研究

New Frontiers in Our Understanding of Lymphatic Malformations of the Head and Neck: Natural History and Basic Research.

作者信息

Perkins Jonathan A

机构信息

Otolaryngology/Head and Neck Surgery, University of Washington School of Medicine, 1959 Pacific Avenue NE, Box 366515, Seattle, WA 98195, USA; Vascular Anomalies Program, Seattle Children's Hospital, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

出版信息

Otolaryngol Clin North Am. 2018 Feb;51(1):147-158. doi: 10.1016/j.otc.2017.09.002.

DOI:10.1016/j.otc.2017.09.002
PMID:29217059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5726598/
Abstract

The future of head and neck lymphatic malformation (HNLM) evaluation and treatment is changing because of 2 decades of clinical research and recent basic science investigation. Basic science investigation using cellular biology and molecular genetics has revealed the genetic cause of some HNLMs, which has created the possibility of medical treatment specific to HNLM. This article summarizes the clinical and basic science research that will likely influence the future of HNLM assessment and treatment.

摘要

由于二十年的临床研究以及近期的基础科学调查，头颈部淋巴管畸形（HNLM）评估与治疗的未来正在发生变化。运用细胞生物学和分子遗传学的基础科学调查揭示了一些HNLM的遗传病因，这为针对HNLM的医学治疗创造了可能性。本文总结了可能会影响HNLM评估与治疗未来发展的临床和基础科学研究。