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Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling.
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FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.
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The STIM1-binding site nexus remotely controls Orai1 channel gating.
Nat Commun. 2016 Dec 8;7:13725. doi: 10.1038/ncomms13725.
2
Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.
Biophys J. 2016 Nov 1;111(9):1897-1907. doi: 10.1016/j.bpj.2016.09.020.
3
The Orai1 Store-operated Calcium Channel Functions as a Hexamer.
J Biol Chem. 2016 Dec 9;291(50):25764-25775. doi: 10.1074/jbc.M116.758813. Epub 2016 Oct 25.
4
Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.
J Clin Invest. 2016 Nov 1;126(11):4303-4318. doi: 10.1172/JCI89056. Epub 2016 Oct 10.
5
Cholesterol modulates Orai1 channel function.
Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.
6
Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):440-5. doi: 10.1073/pnas.1523410113. Epub 2015 Dec 28.
7
A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.
Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901.
8
TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling.
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7083-92. doi: 10.1073/pnas.1521924112. Epub 2015 Dec 7.
9
Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1).
J Biol Chem. 2016 Jan 1;291(1):334-41. doi: 10.1074/jbc.M115.685289. Epub 2015 Nov 6.
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Diseases caused by mutations in ORAI1 and STIM1.
Ann N Y Acad Sci. 2015 Nov;1356(1):45-79. doi: 10.1111/nyas.12938. Epub 2015 Oct 15.
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