Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Family Medicine, Yong-In Severance Hospital, Yonsei University College of Medicine, Yong-In, Republic of Korea.
Clin Chim Acta. 2018 Feb;477:113-118. doi: 10.1016/j.cca.2017.12.004. Epub 2017 Dec 5.
The aim of this study was to examine the relationship between platelet count and sarcopenic obesity in postmenopausal women.
This cross-sectional study was conducted using nationally representative data. A total of 2810 postmenopausal women who participated in the 2008-2011 Korea National Health and Nutrition Examination Survey were included in this study. Sarcopenic obesity was defined by a sarcopenia criterion and an obesity criterion. Platelet counts were divided into quartiles as follows: Q, 150-222; Q2, 223-257; Q3, 258-294, and Q4, 295-450 (10/μl). Multiple logistic regression analysis was performed to examine the association between platelet count quartile and sarcopenic obesity after adjusting for confounding factors.
The prevalence of sarcopenic obesity in postmenopausal women was 14.8%. Compared to the lowest platelet quartile, the odds ratios and 95% confidence intervals for sarcopenic obesity in the highest quartile were 1.98 (1.36-2.89) in the unadjusted model; 1.93 (1.31-2.83) after adjusting for age; and 1.65 (1.23-2.65) after adjusting for age, systolic blood pressure, homeostatic model assessment insulin resistance (HOMA-IR), triglyceride, total cholesterol, total calorie intake, regular exercise, current smoking status, and education level.
Elevated platelet count (i.e. towards the upper end of the normal range) was significantly associated with sarcopenic obesity in postmenopausal women.
本研究旨在探讨血小板计数与绝经后妇女肌少症性肥胖的关系。
本横断面研究使用全国代表性数据进行。共纳入 2008-2011 年韩国国家健康和营养调查中 2810 名绝经后妇女。肌少症性肥胖根据肌少症标准和肥胖标准定义。血小板计数分为四等分：Q1，150-222；Q2，223-257；Q3，258-294，Q4，295-450（10/μl）。调整混杂因素后，采用多因素 logistic 回归分析血小板计数四分位与肌少症性肥胖的关系。
绝经后妇女肌少症性肥胖的患病率为 14.8%。与最低血小板四分位相比，最高血小板四分位的肌少症性肥胖比值比及其 95%置信区间在未调整模型中为 1.98（1.36-2.89）；调整年龄后为 1.93（1.31-2.83）；调整年龄、收缩压、稳态模型评估胰岛素抵抗（HOMA-IR）、甘油三酯、总胆固醇、总热量摄入、规律运动、当前吸烟状况和教育水平后为 1.65（1.23-2.65）。
血小板计数升高（即接近正常范围上限）与绝经后妇女肌少症性肥胖显著相关。
