Chaudhary Devendra, Ahluwalia Rahul, Rai Arvind
Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India.
29, South Avenue, Choubey Colony, Opp. Chhattisgarh Hospital, Raipur, Chhattisgarh 492001 India.
Indian J Surg. 2017 Dec;79(6):544-548. doi: 10.1007/s12262-016-1524-8. Epub 2016 Jul 16.
Out of a total of 50 study-eligible patients, 15 patients were found to have synchronous breast cancer and gallbladder diseases. Fourteen such patients had breast cancer and cholelithiasis while 1 patient had breast cancer with gallbladder cancer. Amongst these 15 patients, 7 patients tested positive for chromosomal aberrations on karyotyping. Aberrations in these patients were seen on chromosomes 13 and 17 with 2 patients having deletion 13q, 2 having deletion 17q, and 2 having deletions on 17p while one patient had multiple deletions on chromosomes 13q and 17p. The patient with multiple aberrations on 13q and 17p had a grade III infiltrating ductal carcinoma (NOS) of the breast with adenocarcinoma of the gallbladder. On the basis of our study and its analysis, we conclude that synchronous breast and gallbladder lesions are common amongst females and the occurrence of one should warn the clinician to search for the other. Also, chromosomal aberrations are common amongst patients with synchronous diseases and since these abnormalities are in the germ line cells, genetic counselling should be offered to the first- and second-degree female relatives.
在总共50名符合研究条件的患者中，发现15名患者同时患有乳腺癌和胆囊疾病。其中14名患者患有乳腺癌和胆结石，1名患者患有乳腺癌合并胆囊癌。在这15名患者中，7名患者在核型分析时染色体异常检测呈阳性。这些患者的染色体13和17出现异常，2名患者有13q缺失，2名有17q缺失，2名有17p缺失，1名患者在染色体13q和17p上有多处缺失。13q和17p有多处异常的患者患有乳腺III级浸润性导管癌（非特殊类型）合并胆囊腺癌。基于我们的研究及其分析，我们得出结论，女性中同时出现乳腺和胆囊病变很常见，出现其中一种病变应提醒临床医生排查另一种病变。此外，染色体异常在同时患有这两种疾病的患者中很常见，由于这些异常存在于生殖细胞中，应该为一级和二级女性亲属提供遗传咨询。
